Prediabetes

A post-hoc analysis of the German Prediabetes Lifestyle Intervention Study has found that people who achieve remission of prediabetes by losing weight through lifestyle intervention for 12 months may reduce their risk for developing type 2 diabetes.

Using liraglutide in people with obesity and prediabetes is a valuable strategy for weight loss, but improvements are greater with caloric restriction alone, suggest study results.

People who have heart failure with preserved ejection fraction benefit from dapagliflozin irrespective of whether they have normal or impaired glucose metabolism, shows further analysis of DELIVER.

Diabetes has a stronger association with the risk for kidney cancer in women than men, despite men being overall more likely to develop the malignancy, shows a nationwide cohort study from Korea.

People with a South Asian or mixed ethnic background and those with social deprivation have a particularly high risk for progressing from prediabetes to type 2 diabetes, research shows.

Researchers have identified localized white matter microstructural damage in people with prediabetes and widespread abnormalities in those with type 2 diabetes.

Even small increases in the number of steps taken in a day is associated with a reduced risk for mortality in people with prediabetes or diabetes, say researchers.

Smoking is associated with an increased risk for albuminuria in both people with prediabetes and those with diabetes, but quitting may not immediately circumvent this risk, researchers report.

People with impaired glucose tolerance who received metformin or intensive lifestyle intervention during the DPP trial show no sign of a significantly reduced cardiovascular disease risk 21 years later, reveal the latest DPPOS results.

Daily treatment with the vitamin D analog eldecalcitol has not prevented the development of type 2 diabetes or promoted a return to normoglycemia in a study of Japanese adults with impaired glucose tolerance.

Researchers recommend using different BMI or age thresholds for type 2 diabetes screening in ethnic minority groups, on finding that a single threshold may miss many cases in non-White Americans.

People with hypertension and prediabetes have significantly lower capillary density in the foveal retinal region, indicating microvascular damage, than those with hypertension but normal glucose metabolism, say researchers.

People with glycated hemoglobin levels just below the diabetes diagnosis threshold have the greatest risk for major adverse cardiovascular events and death, suggests a study of individuals in the upper normal glycemic range.

The degree of non-alcoholic fatty liver disease, estimated by fatty liver index, is significantly associated with the risk for progression to type 2 diabetes in people with prediabetes, Spanish study findings indicate.

UK researchers suggest raising the glycated hemoglobin threshold that is used to identify individuals at high risk for developing type 2 diabetes within 5 years.

The US Preventive Services Task Force has recommended lowering the age of screening for prediabetes and type 2 diabetes to 35 years for people with overweight or obesity.

A randomized trial demonstrates significant reductions in visceral adipose tissue in people with obesity but without diabetes taking the glucagon-like peptide-1 receptor agonist liraglutide.

Divergent changes in brain activity after bariatric surgery versus a very-low-calorie diet may help explain why people are more likely to regain weight after the latter intervention, a study suggests.

Taking semaglutide 2.4 mg can reduce the likelihood of people with overweight or obesity developing type 2 diabetes, shows further analysis of STEP 1.

Higher daily glucose variability is associated with greater aortic stiffness irrespective of average glucose levels, indicate findings from The Maastricht Study.