Prediabetes

Smoking is associated with an increased risk for albuminuria in both people with prediabetes and those with diabetes, but quitting may not immediately circumvent this risk, researchers report.

The degree of non-alcoholic fatty liver disease, estimated by fatty liver index, is significantly associated with the risk for progression to type 2 diabetes in people with prediabetes, Spanish study findings indicate.

UK researchers suggest raising the glycated hemoglobin threshold that is used to identify individuals at high risk for developing type 2 diabetes within 5 years.

The risk for subclinical atherosclerosis among people at low risk for cardiovascular death increases with increasing glycated hemoglobin levels and is raised even at levels below the prediabetes threshold, research shows.

Prediabetes is associated with an elevated risk for all-cause mortality and cardiovascular events, both in the general population and in patients with atherosclerotic cardiovascular disease, shows an updated meta-analysis published in The BMJ.

The increased risk for prediabetes among ethnic minorities compared with White people is less pronounced in neighborhoods with high walkability, shows a Canadian study.

A study shows marked variations in cardiovascular risk burden according to age, sex, and ethnicity at the point of type 2 diabetes diagnosis, with implications for both diabetes prevention and cardiovascular risk management.

Insulin resistance may be a more important determinant of type 2 diabetes risk in Chinese people than impaired beta-cell function, show findings from a large population-based study.

Insomnia bestows a degree of risk for type 2 diabetes on patients who already have prediabetes that “is similar to that conferred by traditional risk factors,” according to researchers.

Rubio-Almanza M, Cámara-Gómez R, Hervás-Marín D et al. BMC Endocr Disord 2018; 18: 90. doi: 10.1186/s12902-018-0317-4

Less stringent criteria for gestational diabetes remain predictive of risk for later prediabetes or type 2 diabetes despite identifying a larger number of women, the HAPO FUS investigators report in JAMA.

Gingras V, Hivert MF, Oken E. Curr Diab Rep 2018; 18: 89. doi: 10.1007/s11892-018-1050-0

Physical inactivity is a “significant but underappreciated contributor” to the risk of developing diabetes in people who are already at high risk and should be routinely measured in clinical trials, say the NAVIGATOR investigators.

Jiang L et al. Diabetes Care 2018; 41: 1462–1470. doi: 10.2337/dc17-2685

Chen ME, Aguirre RS, Hannon TS. Curr Diab Rep 2018; 18: 51. doi: 10.1007/s11892-018-1023-3

Thankappan KR et al. PLoS Med 2018; 15: e1002575. doi: 10.1371/journal.pmed.1002575

Saetung S et al. Acta Diabetol 2018. doi: 10.1007/s00592-018-1166-3

Vajravelu ME, Lee JM. Curr Diab Rep 2018; 18: 43. doi: 10.1007/s11892-018-1012-6

Juarez LD et al. Diabetes Res Clin Prac 2018. doi: 10.1016/j.diabres.2018.05.009

Adding body fat percentage to BMI improves the classification of individuals at risk for abnormal blood glucose, US researchers report.