medwireNews: Physical inactivity is a “significant but underappreciated contributor” to the risk of developing diabetes in people who are already at high risk and should be routinely measured in clinical trials, say the NAVIGATOR investigators.
All patients in NAVIGATOR had impaired glucose tolerance and either cardiovascular disease or a high risk of developing it. Their physical activity was measured for 7 days at baseline, using a pedometer, and each 2000-step increase in daily physical activity was associated with a 5.5% reduction in developing diabetes during follow-up, which persisted after accounting for multiple variables.
William Kraus (Duke University School of Medicine, Durham, North Carolina, USA) and co-researchers note that a lifestyle intervention including physical activity did not influence cardiovascular outcomes in people with established type 2 diabetes in the LOOK AHEAD trial, and suggest that “the state of the vasculature in those with established disease is not amenable to modification by lifestyle interventions.”
The analysis is published in BMJ Open Diabetes Research & Care.
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