Pediatric diabetes and hypoglycemia

Data from the DPV cohort show a reduced risk for severe hypoglycemia and diabetic ketoacidosis among children and young people with type 1 diabetes using continuous glucose monitoring rather than self-monitored blood glucose.

Analysis of childhood type 1 diabetes diagnoses across 13 countries indicates that the conditions created by the COVID-19 pandemic worsened pre-existing increasing trends in ketoacidosis at diagnosis.

The iLet bionic pancreas closed-loop insulin delivery system provides good glucose control without the need for the user to count carbohydrates, show findings from the pivotal trial.

Young people with type 1 diabetes are at increased risk for hospitalization for acute complications at the time of transition from pediatric to adult care, say researchers.

Impaired hypoglycemia awareness is present in a substantial proportion of children and young people with type 1 diabetes and is associated with an increased risk for severe hypoglycemia, suggests research presented at the virtual 57th EASD Annual Meeting.

Using a linear insulin to carbohydrate ratio to determine breakfast insulin requirements leads to significant differences in time in glycemic range and hypoglycemia rates when meal carbohydrate quantities vary, shows a study in children and young adults.

Dasiglucagon, a next-generation glucagon analog in a ready-to-use formulation, rapidly restores plasma glucose levels following severe hypoglycemia in children and adolescents with type 1 diabetes, show findings from a phase 3 trial.

Fear of hypoglycemia, rather than the actual frequency of hypoglycemic events, may impact diabetes-specific quality of life in adolescents, say researchers.

The use of continuous glucose monitoring does not increase time in range in young children with type 1 diabetes, but may improve other glycemic indices, researchers report.

Acute kidney injury is common in children with diabetic ketoacidosis and is associated with circulatory volume depletion, greater acidosis, and signs of cerebral injury, US study data show.

Research shows moderate or severe diabetic ketoacidosis is associated with lower IQ and reduced short- and long-term memory in children with type 1 diabetes, with some impairment seen even in newly diagnosed children.

Researchers have identified a marked increase in the proportion of children and adolescents who have diabetic ketoacidosis at the point of type 1 diabetes diagnosis during the COVID-19 pandemic.

Continuous glucose monitoring is well accepted and reduces time in hypoglycemia among older individuals with type 1 diabetes, report researchers in JAMA.

A major study of children from three continents suggests that diabetic ketoacidosis remains unacceptably high among those newly identified with type 1 diabetes and shows few signs of improving.

Age at type 1 diabetes diagnosis does not appear to affect glycemic control and comorbidity once disease is established, but important differences occur between age groups at the time of diagnosis, US study data show.

People with type 1 diabetes using the Tandem Control-IQ hybrid closed-loop insulin delivery system spent significantly more time within their target blood glucose range than people using a sensor-augmented insulin pump during 6 months of use in the iDCL trial.

Implementing a nursing protocol that includes point-of-care testing at triage reduces the time to diabetic ketoacidosis diagnosis and the number of unnecessary intravenous placements in the pediatric emergency department, say researchers.

Children with type 1 diabetes are more likely than their non-diabetic peers to seek primary care for a number of specific conditions in the year before their diagnosis, which could aid detection before the onset of diabetic ketoacidosis, say researchers.

The Tandem Basal-IQ predictive low-glucose suspend insulin delivery system significantly reduces the proportion of time adults and children spend in hypoglycemia during 24-hour usage, show findings from the randomized crossover PROLOG trial.

Almost half of young adults with type 1 diabetes do not see a diabetes physician for more than a year during their transition from pediatric to adult care, and this lack of contact is associated with an increased risk for complications, Canadian research shows.