Pathogenesis

Researchers have characterized an atypical form of diabetes in Indian men with low BMI, which has a unique metabolic profile setting it apart from type 1 and type 2 diabetes.

Phil Zeitler discusses the pathophysiology of type 2 diabetes in children, and why it is so resistant to conventional management (2:58). 

At least a third of people diagnosed with type 2 diabetes in sub-Saharan Africa are neither overweight nor particularly insulin resistant, say researchers.

A genetic propensity for increased liver fat and lower pancreatic volume is associated with an increased risk for type 2 diabetes, say researchers.

A recurring brief intensive course of insulin every 3 months does not build on metabolic improvements gained from an induction course in people with type 2 diabetes of relatively short duration, say researchers.

Researchers have used Mendelian randomization analysis to demonstrate a shared etiology between resting heart rate and the risk for type 2 diabetes.

The failure of intensive medication to halt beta-cell decline in children with early type 2 diabetes occurs despite them having better baseline beta-cell and alpha-cell function than newly diagnosed adults, say the RISE researchers.

Genetic liability to type 2 diabetes manifests in altered lipid profiles from as early as 8 years of age, say researchers.

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