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05-20-2015 | Obesity | Review | Article

Can Genetics Modify the Influence of Healthy Lifestyle on Lipids in the Context of Obesity and Type 2 Diabetes?

Current Cardiovascular Risk Reports

Authors: Gordon S. Huggins, Samantha Berger, Jeanne M. McCaffery

Publisher: Springer US


Recently, the Look AHEAD (Action for Health in Diabetes) trial tested whether randomized lifestyle intervention improves health outcomes among overweight or obese individuals with type 2 diabetes mellitus (T2D). The relatively large sample size for a clinical trial, excellent follow-up, and longitudinal measures make possible the analysis of whether genetic factors can modify behavioral change responses on common traits relevant to cardiovascular health. Despite challenges, emerging examples indicate that genetic factors may alter the magnitude of weight loss and lipid change in response to behavioral treatment. The current challenge is to develop better ways to identify genetic variants that modify lifestyle responses to maximize the clinical impact of genetic discovery.

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