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02-09-2018 | Neuropathy | Review | Article

Diabetic Painful Neuropathy and Restless Legs Syndrome in Diabetes

Journal: Diabetes Therapy

Authors: Sanjay Kalra, Anu Gupta

Publisher: Springer Healthcare

Abstract

Restless legs syndrome (RLS) and diabetic painful neuropathy (DPN) are two distinct neurological conditions, which share many similarities. As RLS occurs frequently in persons with diabetes, the differential diagnosis and management of RLS and DPN may pose a clinical challenge. This communication describes the etiopathogenesis, clinical features, investigations, and treatment of both conditions. It highlights the similarities and differences between RLS and DPN, and helps the physician plan a rational clinical and therapeutic approach.
Literature
1.
American Diabetes Association. 10. Microvascular complications and foot care: standards of medical care in diabetes—2018. Diabetes Care. 2018;41(1):S105–18.CrossRef
2.
Allen RP, Picchietti DL, Garcia-Borreguero D, et al. Restless legs syndrome/Willis–Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria–history, rationale, description, and significance. Sleep Med. 2014;15(8):860–73.CrossRefPubMed
3.
Earley CJ. Latest guidelines and advances for treatment of restless legs syndrome. J Clin Psychiatr. 2014;75(4):08.CrossRef
4.
Earley CJ, Connor J, Garcia-Borreguero D, et al. Altered brain iron homeostasis and dopaminergic function in restless legs syndrome (Willis–Ekbom disease). Sleep Med. 2014;15(11):1288–301.CrossRefPubMed
5.
Sahay M, Kalra S, Tiwaskar M, et al. Indian College of Physicians position statement on anemia in metabolic syndrome. J Assoc Physicians India. 2017;65(6):60.PubMed
6.
Pop-Busui R, Boulton AJ, Feldman EL, et al. Diabetic neuropathy: a position statement by the American Diabetes Association. Diabetes Care. 2017;40(1):136–54.CrossRefPubMed
7.
Yang WS, Yoo JH, Cheon SM, et al. Restless legs syndrome in children and adolescents with type 1 diabetes. Sleep Med Psychophysiol. 2015;22(1):20–4.CrossRef
8.
Beltran Filho AO, Jung GA, Zoehler LV, Cortez J, Lima AV. Evaluation of restless legs syndrome symptoms in patients with and without the diagnosis of type 2 diabetes mellitus. Diabetol Metab Syndr. 2015;7(1):A89.CrossRef
9.
Innes KE, Kandati S, Flack KL, Agarwal P, Selfe TK. The association of restless legs syndrome to history of gestational diabetes in an Appalachian primary care population. J Clin Sleep Med. 2015;11(10):1121.CrossRefPubMedPubMedCentral
10.
Giannaki CD, Hadjigeorgiou GM, Karatzaferi C, Pantzaris MC, Stefanidis I, Sakkas GK. Epidemiology, impact, and treatment options of restless legs syndrome in end-stage renal disease patients: an evidence-based review. Kidney Int. 2014;85(6):1275–82.CrossRefPubMed
11.
Vargas-Perez NJ, Bagai K, Walters AS. Cardiovascular comorbidity in patients with restless legs syndrome; current perspectives. J Parkinsonism Restless Legs Syndr. 2017;1(55):13–28.CrossRef
12.
Szentkirályi A, Völzke H, Hoffmann W, Trenkwalder C, Berger K. Multimorbidity and the risk of restless legs syndrome in 2 prospective cohort studies. Neurology. 2014;82(22):2026–33.CrossRefPubMed
13.
Kalra S, Gupta Y. Good clinical sense in diabetology. J Pak Med Assoc. 2015;65(8):904–6.PubMed
14.
Kalra S, Baruah MP, Das AK. Diabetes therapy by the ear: a bi-directional process. Ind J Endocrinol Metab. 2015;19(1):S4.CrossRef
15.
Garcia-Borreguero D, Silber MH, Winkelman JW, et al. Guidelines for the first-line treatment of restless legs syndrome/Willis–Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med. 2016;31(21):1–11.CrossRefPubMed
16.
Silber MH, Becker PM, Buchfuhrer MJ, et al (2018) The appropriate use of opioids in the treatment of refractory restless legs syndrome. Mayo Clin Proc 93(1):59–67

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