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Support for metformin cardioprotective effect

Heartbeat

Findings from the SAVOR-TIMI 53 trial suggest that metformin treatment reduces cardiovascular and all-cause mortality but not nonfatal cardiovascular disease events, but a meta-analysis points to wider benefits.

medwireNews editor's pick

Targeting pathophysiology from outset may slow progression to type 2 diabetes

Pills_two types

Upfront treatment with medications that target the underlying pathophysiology of prediabetes may slow patients’ progression to type 2 diabetes, report researchers.

Case study

Acute illness while on a SGLT2 inhibitor and ketogenic diet

AdobeStock_88855376

Advisory Board member Theresa Smyth tackles an emergency case involving a type 2 diabetes patient on a new diet and treated with empagliflozin. What went wrong and how should he be managed? [Read more].

Get more on: SGLT2 inhibitors | Diet and nutritional management

medwireNews editor's pick

Poor availability, affordability compromise global diabetes medication use

Global health

Diabetes medications are frequently unavailable and unaffordable, particularly in lower-income countries, shows an analysis of the PURE study.

medwireNews editor's pick

Continuing metformin advisable for patients starting sulfonylurea treatment

Metformin formula

Research shows that starting second-line sulfonylurea treatment is associated with an increased risk for cardiovascular and hypoglycemic events among patients with type 2 diabetes in clinical practice, although the risk is less if they continue using metformin rather than switching completely.

Journal article

Pioglitazone use and risk of bladder cancer: A systematic literature review and meta-analysis of observational studies

Bladder cancer (illustration)

This meta-analysis of observational studies assesses the association between risk of bladder cancer and exposure to pioglitazone among subjects with type 2 diabetes [read more].
Mehtälä J et al. Diabetol Int 2018. doi: 10.1007/s13340-018-0360-4

Get more on:  Diabetic complications | Medication | Type 2 diabetes

medwireNews editor’s pick

First trimester metformin exposure unlikely to raise congenital anomaly risk

Pregnancy

A European-wide case–control study finds little evidence for risk to the developing fetus if a mother is taking metformin.

Journal article

Chronic kidney disease-induced insulin resistance: Current state of the field

Kidneys and urinary bladder (illustration)

This review will evaluate mechanisms responsible for chronic kidney disease-induced insulin resistance and therapies currently available [read more].
Dave N, Wu J, Thomas S. Curr Diab Rep 2018; 18: 44. doi: 10.1007/s11892-018-1010-8

Get more on:  Diabetic complications | Type 1 diabetes | Type 2 diabetes

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RISE: Early insulin does not slow beta cell decline in youth with type 2 diabetes

Islet cells

The RISE trial investigators have found that increased insulin resistance and hyperresponsive beta cells may explain the rapid progression of type 2 diabetes in children.

Journal article

Successful management of poorly controlled type 2 diabetes with multidisciplinary neurobehavioral rehabilitation: A case report and review

Smiling doctors

We present one successful case that demonstrates a significantly beneficial effect of physical exercise and lifestyle intervention in the management of type 2 diabetes mellitus [read more].
Deng Z et al. Diabetes Ther 2018. doi: 10.1007/s13300-018-0448-7

Get more on: Type 2 diabetes | Physical activity | Lifestyle interventions​​​​​​​

medwireNews

09-18-2019 | Vildagliptin | EASD 2019 | News

Trial results VERIFY first-line combination therapy for type 2 diabetes

Upfront combination therapy with vildagliptin and metformin is more durable than metformin alone, and appears to have a legacy effect, report the VERIFY investigators.

08-06-2019 | Metformin | Highlight | News

Support for metformin cardioprotective effect

Findings from the SAVOR-TIMI 53 trial suggest that metformin treatment reduces cardiovascular and all-cause mortality but not nonfatal cardiovascular disease events, but a meta-analysis points to wider benefits.

07-15-2019 | Medications | News

Second-line type 2 diabetes therapies vary globally

Second-line therapy choices for people with type 2 diabetes vary widely throughout the world and are influenced not only by clinical characteristics but also non-medical factors such as affordability and availability, results from the DISCOVER study show.

Themed collections

05-22-2017 | Heart failure | Themed collection | Collection

Heart failure and diabetes mellitus

This collection provides an overview of the epidemiology, underlying pathophysiological mechanisms, screening, assessment and management of heart failure in patients with diabetes mellitus.

Journal articles and book chapters

09-05-2018 | Older adults | Review | Article

Diabetes treatment in the elderly: Incorporating geriatrics, technology, and functional medicine

Valencia WM et al. Curr Diab Rep 2018; 18: 95. doi: 10.1007/s11892-018-1052-y

Guidelines

A convenient single access point, providing diabetes professionals with links to a comprehensive set of clinical practice guidelines from a wide range of relevant organizations.

Slides

Downloadable PowerPoint slide sets containing a variety of high-quality images and illustrations from Springer Nature’s library of published figures.

Practice tips

Practical information, guidance, and helpful resources for diabetes healthcare providers. Comprised of practical approaches, case studies, and more.

Themed collections

Compendia of selected, recently published, free full-text journal and book content from Springer Nature and other publishers on a particular topic within diabetes management, as recommended by our Editorial Board.

Independent Medical Education

Educational programs building upon the most current research and professional practice recommendations, with the aim of enabling more efficient diagnosis, optimizing treatment, and improving patient outcomes.

Image Credits