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Metformin

ADA 2020

DPPOS: No change to cancer risk with long-term metformin use

Tablet device showing the chemical structure of Metformin

Among the latest findings from the DPP Outcomes Study is that long-term use of metformin does not affect the risk for cancer.

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Preoperative metformin use associated with better outcomes after major surgery

Tablet device showing the chemical structure of Metformin

People with type 2 diabetes who are treated with metformin prior to undergoing major surgical interventions may have better postoperative outcomes than those without exposure to the drug, researchers report.

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Further support for early combination therapy in type 2 diabetes

VERIFY trial results

Adding the DPP-4 inhibitor sitagliptin to first-line metformin therapy may delay the need for exogenous insulin among people with type 2 diabetes, researchers report.

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Support for metformin cardioprotective effect

Heartbeat

Findings from the SAVOR-TIMI 53 trial suggest that metformin treatment reduces cardiovascular and all-cause mortality but not nonfatal cardiovascular disease events, but a meta-analysis points to wider benefits.

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Targeting pathophysiology from outset may slow progression to type 2 diabetes

Pills_two types

Upfront treatment with medications that target the underlying pathophysiology of prediabetes may slow patients’ progression to type 2 diabetes, report researchers.

Case study

Acute illness while on a SGLT2 inhibitor and ketogenic diet

AdobeStock_88855376

Advisory Board member Theresa Smyth tackles an emergency case involving a type 2 diabetes patient on a new diet and treated with empagliflozin. What went wrong and how should he be managed? [Read more].

Get more on: SGLT2 inhibitors | Diet and nutritional management

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Poor availability, affordability compromise global diabetes medication use

Global health

Diabetes medications are frequently unavailable and unaffordable, particularly in lower-income countries, shows an analysis of the PURE study.

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Continuing metformin advisable for patients starting sulfonylurea treatment

Metformin formula

Research shows that starting second-line sulfonylurea treatment is associated with an increased risk for cardiovascular and hypoglycemic events among patients with type 2 diabetes in clinical practice, although the risk is less if they continue using metformin rather than switching completely.

Journal article

Pioglitazone use and risk of bladder cancer: A systematic literature review and meta-analysis of observational studies

Bladder cancer (illustration)

This meta-analysis of observational studies assesses the association between risk of bladder cancer and exposure to pioglitazone among subjects with type 2 diabetes [read more].
Mehtälä J et al. Diabetol Int 2018. doi: 10.1007/s13340-018-0360-4

Get more on:  Diabetic complications | Medication | Type 2 diabetes

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First trimester metformin exposure unlikely to raise congenital anomaly risk

Pregnancy

A European-wide case–control study finds little evidence for risk to the developing fetus if a mother is taking metformin.

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10-16-2020 | Older adults | News

Metformin use might have neuroprotective effects in older patients with type 2 diabetes

Results from an observational study suggest that the use of metformin in older patients with type 2 diabetes is associated with a reduced decline in both global cognition and executive function, and a decreased risk for dementia.

08-28-2020 | Metformin | News

Early risk for anemia associated with metformin use in type 2 diabetes

Metformin consistently causes an early reduction in hemoglobin and increases the risk for moderate anemia in patients with type 2 diabetes, a MASTERMIND consortium analysis shows.

06-30-2020 | Medications | News

Network meta-analysis highlights research gaps for diabetes medications

A wide-ranging network meta-analysis published in the Annals of Internal Medicine reveals critical knowledge gaps in the use of glucose-lowering medications in people with type 2 diabetes.

Themed collections

05-22-2017 | Heart failure | Themed collection | Collection

Heart failure and diabetes mellitus

This collection provides an overview of the epidemiology, underlying pathophysiological mechanisms, screening, assessment and management of heart failure in patients with diabetes mellitus.

Journal articles and book chapters

09-05-2018 | Older adults | Review | Article

Diabetes treatment in the elderly: Incorporating geriatrics, technology, and functional medicine

Valencia WM et al. Curr Diab Rep 2018; 18: 95. doi: 10.1007/s11892-018-1052-y

Guidelines

A convenient single access point, providing diabetes professionals with links to a comprehensive set of clinical practice guidelines from a wide range of relevant organizations.

Slides

Downloadable PowerPoint slide sets containing a variety of high-quality images and illustrations from Springer Nature’s library of published figures.

Practice tips

Practical information, guidance, and helpful resources for diabetes healthcare providers. Comprised of practical approaches, case studies, and more.

Themed collections

Compendia of selected, recently published, free full-text journal and book content from Springer Nature and other publishers on a particular topic within diabetes management, as recommended by our Editorial Board.

Independent Medical Education

Educational programs building upon the most current research and professional practice recommendations, with the aim of enabling more efficient diagnosis, optimizing treatment, and improving patient outcomes.

Image Credits