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Monogenic diabetes

Monogenic diabetes

09-22-2022 | EASD 2022 | Conference coverage | News

Support for tailored genetic counseling in people with incidentally discovered MODY mutations

Mutations in HNF1A and HNF4A are less likely to be associated with a diagnosis of maturity-onset diabetes of the young when discovered incidentally versus in a clinically selected cohort, research suggests.

06-08-2022 | ADA 2022 | Conference coverage | News

First-in-class glucokinase activator dorzagliatin could help treat some GK-MODY patients

Dorzagliatin treatment has increased insulin secretion and improved beta-cell function in patients with glucokinase maturity-onset diabetes of the young, also known as MODY2, in a small phase 1 trial.

06-07-2022 | ADA 2022 | Conference coverage | News

Case series suggests SGLT2 inhibitors could be useful add-on therapy for MODY3

Results from a small case series in Denmark suggest SGLT2 inhibitors could be a useful add-on therapy for people with maturity-onset diabetes of the young.

11-08-2021 | Genetics | News

Novel diabetes gene identified

Mutations in the ONECUT1 gene can underlie neonatal diabetes and contribute to the risk for early-onset type 2 diabetes, research shows.

06-26-2021 | ADA 2021 | Conference coverage | News

Genetic influence stronger for youth- than adult-onset type 2 diabetes

The effect of common genetic variants on the risk for type 2 diabetes is markedly stronger for youth-onset than adult-onset disease, report researchers.

09-24-2020 | EASD 2020 | Conference coverage | News

GLIMLINA: Glimepiride–linagliptin combination shows potential for HNF1A-MODY

Adding linagliptin to glimepiride treatment reduces some measures of glycemic variability and improves glycemic control in patients with HNF1A-MODY, indicate findings from the GLIMLINA trial.

11-14-2019 | MODY | News

Islet autoantibody negativity, mild hyperglycemia should trigger MODY genetic screening

Islet autoantibody negativity plus mild hyperglycemia and a family history of diabetes can be used to identify children newly diagnosed with diabetes who should undergo genetic testing for maturity-onset diabetes of the young, study findings indicate.

07-29-2019 | Pathophysiology | News

Cluster analysis may help to predict diabetic complications

Allocating people with diabetes to one of five previously described data-driven clusters may help to identify those at high immediate risk for developing diabetic neuropathy or non-alcoholic fatty liver disease, say researchers.

06-08-2019 | Monogenic diabetes | ADA 2019 | News

Monogenic diabetes mutations prevalent in type 2 diabetes

People with type 2 diabetes have a high prevalence of pathogenic mutations in genes typically associated with monogenic diabetes.

03-07-2019 | Diagnosis | DUKPC 2019 | News

Double-checking C-peptide well after type 1 diagnosis can lead to reclassifications

Measuring C-peptide in everyone a minimum of 3 years after a clinical diagnosis of type 1 diabetes can result in some people being reclassified with other forms of diabetes, researchers report.

10-30-2018 | Monogenic diabetes | Review | Article

Genetics of monogenic diabetes: Present clinical challenges

Misra S, Owen KR. Curr Diab Rep 2018; 18: 141. doi: 10.1007/s11892-018-1111-4

09-26-2018 | Monogenic diabetes | News

Clinical factors predict good glycemic control after MODY treatment switch

Baseline glucose control, diabetes duration, and BMI all impact whether an individual achieves optimal glucose control after a genetic diagnosis and treatment change for maturity onset diabetes of the young, UK researchers report.

06-24-2018 | Adolescents | ADA 2018 | News

Adolescents with diabetes often not getting the psychotherapy services they need

Only a very small proportion of adolescents and young adults with diabetes who are referred for outpatient psychotherapy actually receive these services, even when there is an integrated pediatric psychologist in the clinic, research shows.

06-22-2018 | Monogenic diabetes | Review | Article

Advances in the genetics of youth-onset type 2 diabetes

Todd JN, Srinivasan S, Pollin TI. Curr Diab Rep 2018; 18: 57. doi: 10.1007/s11892-018-1025-1

06-22-2018 | Monogenic diabetes | Review | Article

Monogenic diabetes in children and adolescents: Recognition and treatment options

Sanyoura M, Philipson LH, Naylor R. Curr Diab Rep 2018; 18: 58. doi: 10.1007/s11892-018-1024-2

06-16-2018 | Risk factors | Review | Article

Methods for measuring risk for type 2 diabetes in youth: The oral glucose tolerance test (OGTT)

Chen ME, Aguirre RS, Hannon TS. Curr Diab Rep 2018; 18: 51. doi: 10.1007/s11892-018-1023-3

06-13-2018 | Neonatal diabetes | Review | Article

Congenital diabetes: Comprehensive genetic testing allows for improved diagnosis and treatment of diabetes and other associated features

Letourneau LR, Greeley SAW. Curr Diab Rep 2018; 18: 46. doi: 10.1007/s11892-018-1016-2

Newborn baby

06-05-2018 | Neonatal diabetes | Highlight | News

Reassuring long-term data for sulfonylurea in neonatal diabetes

Sulfonylurea treatment is durably effective with a low rate of side effects in patients with permanent neonatal diabetes caused by mutations in the KCNJ11 gene, a study in The Lancet Diabetes & Endocrinology shows.