Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Dynamics of Insulin Action on Mammary Epithelium

Nature New Biology volume 239, pages 216–217 (1972)Cite this article

Abstract

WE have found that, without entering its target cells, insulin elicits biological effects by impinging on the cell membrane. Furthermore, prolonged contact between hormone and mammary cell membrane is not necessary; transient contact through collisions suffices to produce a biological response.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Cuatrecasas, P., Proc. US Nat. Acad. Sci., 63, 450 (1969).

    Article  CAS  Google Scholar 

  2. Turkington, R. W., Biochem. Biophys. Res. Commun., 41, 1362 (1970).

    Article  CAS  Google Scholar 

  3. Blatt, L. M., & Kim, K.-H., J. Biol. Chem., 246, 4895 (1971).

    CAS  PubMed  Google Scholar 

  4. Oka, T., & Topper, Y. J., Proc. US Nat. Acad. Sci., 68, 2066 (1971).

    Article  CAS  Google Scholar 

  5. Cuatrecasas, P., Proc. US Nat. Acad. Sci., 68, 1264 (1971).

    Article  CAS  Google Scholar 

  6. Freychet, P., Roth, J., & Neville, jun., D. M., Biochem. Biophys. Res. Commun., 43, 400 (1971).

    Article  CAS  Google Scholar 

  7. Kono, T., & Barham, F. W., J. Biol. Chem., 246, 6210 (1971).

    CAS  PubMed  Google Scholar 

  8. Cuatrecasas, P., J. Biol. Chem., 247, 1970 (1972).

    Google Scholar 

  9. Soderman, D. D., Germershausen, J., & Katzen, H. M., Fed. Proc., 31, 486 Abs (1972).

    Google Scholar 

  10. Friedberg, S. H., Oka, T., & Topper, Y. J., Proc. US Nat. Acad. Sci., 67, 1493 (1971).

    Article  Google Scholar 

  11. Bray, G. A., Anal. Biochem., 1, 279 (1960).

    Article  CAS  Google Scholar 

  12. Selinger, R. C. L., & Civen, M., Biochem. Biophys. Res. Commun., 43, 793 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland, 20014

    TAKAMI OKA & YALE J. TOPPER

Authors
  1. TAKAMI OKA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. YALE J. TOPPER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

OKA, T., TOPPER, Y. Dynamics of Insulin Action on Mammary Epithelium. Nature New Biology 239, 216–217 (1972). https://doi.org/10.1038/newbio239216a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio239216a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing