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An evaluation of heart rate variability and its modifying factors in children with type 1 diabetes

Published online by Cambridge University Press:  09 September 2013

Senem Özgür ,
Özben Ceylan ,
Filiz Şenocak ,
Utku A. Örün ,
Vehbi Doğan ,
Osman Yılmaz ,
Mahmut Keskin ,
Zehra Aycan ,
Sercan Okutucu  and
Selmin Karademir
Senem Özgür
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Özben Ceylan*
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Filiz Şenocak
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Utku A. Örün
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Vehbi Doğan
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Osman Yılmaz
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Mahmut Keskin
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Zehra Aycan
Affiliation:
Department of Pediatric Endocrinology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
Sercan Okutucu
Affiliation:
Department of Cardiology, Hacettepe University, Ankara, Turkey
Selmin Karademir
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey
*
Correspondence to: Ö. Ceylan, Department of Pediatric Cardiology, Dr. Sami Ulus Children's Hospital, Babur Street, 44 (06080) Altındag, Ankara, Turkey. Tel: +90 312 305 60 00; Fax: +90 312 317 0353; E-mail: ceylanozben@yahoo.com
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Abstract

Objective: To evaluate heart rate variability by Holter monitoring in type 1 diabetic children compared with a healthy control group and determine the factors modifying heart rate variability. Methods: This was designed as a prospective study comparing 28 patients, diagnosed with type 1 diabetes and under follow-up, with 27 healthy control group subjects. Results: The patients were aged 9.9 ± 4.2 years in the diabetic group, including 13 (46.5%) girls and 15 (53.5%) boys. The healthy control group comprised 20 (74%) girls and seven boys (26%) with an average age of 8.6 ± 3.7 years. The search for factors modifying heart rate variability yielded the following correlations: for the time-dependent variables, negative between age and both average and maximal heart rate (r = −0.263 and −0.460, respectively), negative between haemoglobin A1c and percentage of differences between adjacent RR intervals >50 ms, positive between diabetes duration and square root of the mean of the sum of squares of differences between adjacent NN intervals. The average heart rate and percentage of differences between adjacent RR intervals >50 ms was significantly higher in the girls than the boys in all groups. With regard to the frequency-dependent factors affecting heart rate variability, correlations were found between haemoglobin A1c level and both total power and very low frequency (r = −0.751 and −0.644) and between very low frequency and diabetes duration. Conclusion: A reduction in heart rate variability parameters was observed in type 1 diabetes mellitus patients who had a long disease duration or were poorly controlled, as compared with healthy controls.

Keywords

Heart rate variabilityhaemoglobin A1cPaediatricType 1 diabetes
Type
Original Articles
Information
Cardiology in the Young , Volume 24 , Issue 5 , October 2014 , pp. 872 - 879
Copyright
Copyright © Cambridge University Press 2013 

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