Special presentationPancreas Versus Islet Transplantation in Diabetes Mellitus: How to Allocate Deceased Donor Pancreata?
References (18)
- et al.
Beta-cell replacement therapy (pancreas and islet transplantation)an integrated approach
Endocrinol Metab Clinics North America
(2004) - et al.
The impact of donor obesity on outcomes after cadaver pancreas transplantation
Am J Transplant
(2004) - et al.
Transplant options for patients undergoing total pancreatectomy for chronic pancreatitis
J Am Coll Surg
(2004) - et al.
Evolution of kidney, pancreas, and islet transplantation for patients with diabetes at the University of Minnesota
Am J Surg
(1993) Beta-cell replacement by transplantation in diabetes mellitus
Current Opinion in Organ Transplantation
(2005)Beta-cell replacement for type 1 diabetes mellitus—islet verus solid organ pancreas
Curr Opin Organ Transplant
(2005)- et al.
Surgical techniques for pancreas transplantation
Curr Opin Organ Transplant
(2005) - et al.
Immunosuppression for pancreas transplantation
Curr Opin Organ Transplant
(2005) 2005 updateimpact of pancreas and islet transplantation on acute and chronic complications of diabetes
Curr Opin Organ Transplant
(2005)
Cited by (21)
Overcoming barriers in clinical islet transplantation: Current limitations and future prospects
2014, Current Problems in SurgeryCitation Excerpt :Organ allocation schemes prioritize whole-pancreas transplantation over islet transplantation.32 Currently, the Organ Procurement and Transplantation Network-United Network for Organ Sharing Kidney and Pancreas Transplant Committee preferentially allocate pancreas from older, overweight donors for islet transplantation.79,80 The underlying logic is that pancreata from older donors between 50 and 65 years of age are associated with decreased survival when utilized in whole-organ pancreas transplants; however, on account of their good islet yield, they are allocated for islet transplantation.
Standardization of islet isolation outcome - A new automatic system to determine pancreatic islet viability
2011, Expert Systems with ApplicationsCitation Excerpt :Large islets (high isolation index) are generally considered preferable as compared to smaller islets (low isolation index) since the latter could be indicative of over-digestion and fragmentation of the endocrine tissue and consequent loss of functionality. Contrarily, some investigators have recently proposed an advantage of the smaller islets due to better oxygenation and vascularization post-transplant (Cavallari, Zuellig, Lehmann, Weber, & Moritz, 2007; Kandaswamy & Sutherland, 2006; Lehmann et al., 2007; Nano et al., 2005). Based on reported evidence, purity, described as percentage of islets versus non-endocrine tissue, represents another ambiguous factor.
Multi-Criteria Decision Making support system for pancreatic islet transplantation
2011, Expert Systems with ApplicationsCitation Excerpt :Those include hypoxia, mechanic and enzymatic damage, inflammation, allo and auto immunity, immunosupression, and others. Islet size has been recently investigated in relation to graph function with conflicting conclusions (Cavallari, Zuellig, Lehmann, Weber, & Moritz, 2007; Kandaswamy & Sutherland, 2006; Lehmann et al., 2007). Islet number is a critical indicator of viability and correlates with clinical success (Mahler et al., 1999).
Outcomes of Extended Donors in Pancreatic Transplantation With Portal-Enteric Drainage
2008, Transplantation ProceedingsCitation Excerpt :In addition, deceased donors >50 years have increased from 21% to 31%, and cerebrovascular causes of brain death have risen from 26% to 41%.1 The lack of available pancreata is compounded not only by the overall shortage of organ donors but also by donor pancreatic under-utilization and a resurgence in islet transplantation.2–4,12–14 “Ideal” pancreatic donors are usually between the ages of 10 and 40 years, have a body weight between 30 to 80 kg, have sustained brain death due to head trauma, and have been hospitalized for <48 hours.5–8
Current status of islet transplantation
2007, Cirugia Espanola