Original articleThe Wisconsin Epidemiologic Study of Diabetic Retinopathy XXII: The Twenty-Five-Year Progression of Retinopathy in Persons with Type 1 Diabetes
Section snippets
Study Population
The population, who have been described in previous reports,9, 10, 11, 30, 31, 32, 33 consisted of a sample selected from 10,135 diabetic patients who received primary care in an 11-county area in southern Wisconsin from 1979 to 1980. This sample was composed of all those with “younger-onset” type 1 diabetes and a duration-stratified sample of those with “older-onset” type 1 diabetes. The analyses in this report are limited to the group with younger-onset type 1 diabetes, all of whom were
Characteristics of the Cohort
Characteristics at the baseline examination of those who participated in the 25-year follow-up, those who did not participate because they could not be located or they refused, and those who had died in the 11-year interval between the 14- and 25-year examinations are given in Table 1. With the exception of less education, there were no significant differences in characteristics of those who participated compared with those who survived but did not participate. The 120 persons with
Discussion
The data reported provide unique population-based information regarding the 25-year cumulative rates of progression and improvement of DR and their relationship to glycemia, blood pressure, and other factors in persons with type 1 diabetes mellitus over a period of profound change in the management of this condition. The overall 25-year incidence of any retinopathy (97%), rates of progression of retinopathy (83%), and progression to proliferative retinopathy (42%) were high, and the strongest
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Manuscript no. 2008-303.
Financial Disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in this article.
This research is supported by National Institutes of Health grant EY03083 and EY016379 (Ronald Klein, MD, MPH, Barbara E. K. Klein, MD, MPH) and, in part, by the Research to Prevent Blindness (R. Klein and BEK Klein, Senior Scientific Investigator Awards), New York, NY. The National Eye Institute provided funding for entire study including collection and analyses and of data; RPB provided further additional support for data analyses.