Clinical ResearchMyocardial MetabolismEffects of Hepatic Triglyceride Content on Myocardial Metabolism in Type 2 Diabetes
Myocardial Metabolism
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Key Words
cardiomyopathy
diabetes mellitus
hepatic
magnetic resonance imaging
positron emission tomography
Abbreviations and Acronyms
CAD
coronary artery disease
CVD
cardiovascular disease
[18F]FDG
[18F]-2-fluoro-2-deoxy-d-glucose
LV
left ventricular
MBF
myocardial blood flow
MFAE
myocardial fatty acid esterification
M/I
whole-body insulin sensitivity
MMRglu
myocardial metabolic rate of glucose uptake
[31P]-MR
phosphorus-31 magnetic resonance
PCr/ATP
phosphocreatine/adenosine triphosphate
T2DM
type 2 diabetes mellitus
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This investigator-initiated study was supported by Eli Lilly. Dr. Diamant reports receiving consulting and lecture fees from Eli Lilly, Merck, Novartis, Novo Nordisk, Pfizer, and Sanofi-Aventis and research grants from Eli Lilly, GlaxoSmithKline, Merck, Novartis, and Novo Nordisk. Dr. Heine is employed by Eli Lilly as of January 2008. Drs. Rijzewijk, Jonker, Diamant, and Lamb contributed equally to this work. Michael Davidson, MD, served as Guest Editor for this paper.
Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.