Original articleFour-Year Incidence and Progression of Diabetic Retinopathy and Macular Edema: The Los Angeles Latino Eye Study
Section snippets
Study Population and Design
The Los Angeles Latino Eye Study is a population-based cohort study of eye disease in self-identified Latinos aged 40 years and older living in 6 census tracts in the city of La Puente, Los Angeles County, California. The baseline clinical examination was performed from 2000 to 2003, and the 4-year follow-up examination was performed from 2004 to 2008. At baseline, 6357 participants completed an in-home questionnaire and a clinical ophthalmic examination. Details of the study design, methods,
Results
Of the 6357 participants examined at baseline, 6100 living eligible participants were identified for the 4-year follow-up study, and 4658 (76%) completed the follow-up examination. Of these, 904 had definite diabetes at baseline (of which 69 of 904 [7.6%] were newly diagnosed, and 835 of 904 [92.4%] were previously diagnosed), and 775 had gradable fundus photographs in the same eye at baseline and at follow-up; hence this is the cohort used for the analyses in this paper. Compared to those not
Discussion
In LALES, we found that incidence of DR (28% in first eye) and ME (5% in first eye) in Latinos was high compared to incidence previously reported for U.S. non-Hispanic whites. A higher incidence of DR, ME, or CSME was associated with longer duration of diabetes, despite the fact that incidence of these ocular diseases decreased with age. For example, incidence of DR (in the first eye, second eye, or both) at the 4-year follow-up examination was highest among the youngest age groups (40–49 years
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