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Admission glucose level and in-hospital outcomes in diabetic and non-diabetic patients with acute myocardial infarction

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Abstract

Background

Hyperglycemia on admission is a predictor of unfavorable prognosis in patients with acute myocardial infarction (AMI). Data concerning associations between elevated glucose level on admission and other in-hospital complications are still limited.

Methods

A total of 607 AMI patients with complete admission glucose data in the Krakow Registry of Acute Coronary Syndromes were identified and were stratified according to glucose admission level.

Results

A total of 71.5% of patients were with admission glucose level <7.8 mmol/l, 17.6% of patients with 7.8–11.0 mmol/l, and 10.9% of patients with ≥11.1 mmol/l. In-hospital mortality for patients treated conservatively was higher in patients with higher admission glucose (8.0 vs. 25.0 vs. 39.1%, respectively, P < 0.0001), and significant mortality difference was confirmed both for diabetic and non-diabetic patients. Admission hyperglycemia was associated with increased risk of ventricular tachycardia/ventricular fibrillation, atrial fibrillation, second to third atriventricular block, pulmonary oeadema, but not ischemic stroke and blood transfusion during index hospital stay.

Conclusions

Elevated admission glucose levels are associated with increased risk of life-threatening complications, especially arrhythmias in diabetic and non-diabetic AMI patients. This increased risk of complications is one of the possible explanations for the elevated in-hospital mortality in AMI patients presenting with hyperglycemia.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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Authors and Affiliations

  1. 2nd Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland

    Artur Dziewierz, Dawid Giszterowicz, Zbigniew Siudak, Tomasz Rakowski & Jacek S. Dubiel

  2. Department of Interventional Cardiology, Jagiellonian University Medical College, Kopernika 17 Street, 31-501, Krakow, Poland

    Dariusz Dudek

Authors
  1. Artur Dziewierz
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  2. Dawid Giszterowicz
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  3. Zbigniew Siudak
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  4. Tomasz Rakowski
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  5. Jacek S. Dubiel
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  6. Dariusz Dudek
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Correspondence to Dariusz Dudek.

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Dziewierz, A., Giszterowicz, D., Siudak, Z. et al. Admission glucose level and in-hospital outcomes in diabetic and non-diabetic patients with acute myocardial infarction. Clin Res Cardiol 99, 715–721 (2010). https://doi.org/10.1007/s00392-010-0175-1

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  • DOI: https://doi.org/10.1007/s00392-010-0175-1

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