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Amino Acid Regulation of Autophagosome Formation

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Book cover Autophagosome and Phagosome

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 445))

Summary

Amino acids are not only substrates for various metabolic pathways, but can also serve as signaling molecules controlling signal transduction pathways. One of these signaling pathways is mTOR-dependent and is activated by amino acids (leucine in particular) in synergy with insulin. Activation of this pathway inhibits autophagy. Because activation of mTOR-mediated signaling also stimulates protein synthesis, it appears that protein synthesis and autophagic protein degradation are reciprocally controlled by the same signaling pathway. Recent developments indicate that amino acid–stimulated mTOR-dependent signaling is subject to complex regulation. The mechanism by which amino acids stimulate mTORdependent signaling (and other signaling pathways), and its molecular connection with the autophagic machinery, is still unknown.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef, Amsterdam, The Netherlands

    Alfred J. Meijer

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  1. Alfred J. Meijer
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Editors and Affiliations

  1. Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA

    Vojo Deretic

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Meijer, A.J. (2008). Amino Acid Regulation of Autophagosome Formation. In: Deretic, V. (eds) Autophagosome and Phagosome. Methods in Molecular Biology™, vol 445. Humana Press. https://doi.org/10.1007/978-1-59745-157-4_5

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  • DOI: https://doi.org/10.1007/978-1-59745-157-4_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-853-9

  • Online ISBN: 978-1-59745-157-4

  • eBook Packages: Springer Protocols

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