Regular ArticleInsulin Suppresses the Increased Activities of Lysosomal Cathepsins and Ubiquitin Conjugation System in Burn-Injured Rats
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Insulin Modulates Myogenesis and Muscle Atrophy Resulting From Skin Scald Burn in Young Male Rats
2021, Journal of Surgical ResearchCitation Excerpt :However, in this study, we investigated the effects of insulin treatment on a muscle distant from extensive burn lesion. Regarding experimental studies on extensive BIs and intensive insulin therapy, most authors studied short-term therapy acting in the acute postburn phase, ranging from 1 to 5 d.30-36 Few studies address long-term therapies, for 7,31,32 12,37 and 15 d.38 The results of these studies were based on serology blood tests. However, little is known about the anabolic effect of insulin on skeletal muscle after SI.
Insulin infusion stimulates whole-body protein synthesis and activates the upstream and downstream effectors of mechanistic target of rapamycin signaling in the gluteus medius muscle of mature horses
2014, Domestic Animal EndocrinologyCitation Excerpt :For all 3 treatments in which insulin was infused, at the time of muscle biopsy (120 min), plasma concentrations of essential amino acids were lower than with the CON treatment, and the activation of the downstream mTOR signaling was higher than CON; therefore, it appears that an insulin-mediated increase in muscle protein synthesis was at least partially responsible for the decrease in plasma amino acid concentrations seen with insulin infusion. We did not measure the activation of the pathways involved in muscle protein breakdown in the present study, but, because insulin treatment has been shown to reduce proteosomal and lysosomal protein degradation in mature rodent skeletal muscle [38,39], it is likely that there was also some inhibitory effect of insulin on muscle protein breakdown in our horses, although additional research is necessary to confirm this. Although the rates of mixed muscle protein fractional synthesis were not measured isotopically in the present study, studies in both neonatal piglets [14] and humans [12,13] found that the insulin-mediated increases in the activation of mTOR signaling factors also coincided with an increase in muscle protein synthesis rates.
Molecular mechanisms behind clinical benefits of intensive insulin therapy during critical illness: Glucose versus insulin
2009, Best Practice and Research: Clinical AnaesthesiologyCitation Excerpt :Beneficial effects of insulin were also observed in animal models. For instance, it prevented weight loss in a rabbit model of prolonged critical illness90 and suppressed muscle proteolysis in burn-injured rats, with involvement of the ubiquitin–proteasome pathway and lysosomal proteases.91 However, when considering potential anabolic effects of intensive insulin therapy, a contribution of glycaemic control may not be excluded as it has been shown that hyperglycaemia induces catabolic responses.92,93
Antiproteolytic Action of Orally Delivered Insulin Using pH-Responsive Hydrogels in a Rat Burn Model
2006, Journal of Surgical ResearchInfluence of insulin therapy on burn wound healing in rats
2003, Journal of Surgical Research
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