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Lifestyle interventions and clinical trials

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10-12-2021 | Diet | News

DiRECT insights highlight ‘ongoing struggle’ of maintaining weight loss

Many participants of DiRECT found reintroduction of food and subsequent weight-loss maintenance to be more challenging than the 800 calorie total meal replacement phase, the investigators report.

09-29-2021 | EASD 2021 | Conference coverage | News

Intra-organ fat reduction parallels type 2 diabetes remission in lean people

Outwardly lean people who have type 2 diabetes have increased intra-organ fat, reductions in which occur in line with weight loss-induced diabetes remission, say researchers.

05-31-2021 | Hypertension | News

DiRECT analysis supports antihypertensive withdrawal before very-low-calorie diet

Blood pressure falls markedly when people with type 2 diabetes undertake a very-low-calorie diet, and immediate withdrawal of antihypertensive medications has few ill effects, say the DiRECT investigators.

04-29-2021 | DUKPC 2021 | Conference coverage | News

Liver, pancreatic fat may underlie ‘disproportionately raised’ CV risk in women with diabetes

Women naturally have lower levels of hepatic and pancreatic fat than men, but having type 2 diabetes removes this advantage and confers a relatively larger increase in cardiovascular risk, show further data from DiRECT.

Weight gain

01-12-2021 | Diet | News

Ghrelin changes predict weight regain after DiRECT diet

Ghrelin is the only appetite-related hormone that predicted weight regain among the participants of the DiRECT trial, say the researchers.

10-09-2020 | Diet | News

Pancreatic morphology normalizes with sustained type 2 diabetes remission

Sustained remission of type 2 diabetes in DiRECT was accompanied by normalization of pancreatic morphology, say the researchers.

09-09-2020 | Diet | News

Weight loss strongest predictor of remission in DiRECT

The strongest predictor of type 2 diabetes remission is weight loss, with other variables only modestly associated with outcome and insufficient to identify people unsuitable for attempting this goal, shows a post-hoc analysis of DiRECT data.

Doha, Qatar

05-22-2020 | Diet | News

DIADEM-I expands DiRECT approach to Middle East

The DIADEM-I randomized trial demonstrates substantial remission of type 2 diabetes in people from the Middle East and in north Africa after they undertake a total meal-replacement very-low-calorie diet.

Editor's pick Holiday image

08-07-2019 | Diet | News

DiRECT to the Caribbean

The very-low-calorie diet intervention used in the DiRECT trial is feasible and associated with type 2 diabetes remission in residents of Barbados, researchers report.

06-19-2019 | Diet | ADA 2019 | News

DiRECT: Beta cells ‘not dead’ in type 2 diabetes

People who achieved sustained remission of type 2 diabetes via substantial weight loss in the DiRECT trial regained normal maximal beta-cell capacity, the investigators report.

05-15-2019 | Diet | News

DiRECT/Counterweight-Plus intervention could be cost-effective long-term

Type 2 diabetes remission can be achieved within 1 year at a cost below the average annual cost of diabetes management, even when including complications, shows an economic evaluation of the DiRECT/Counterweight-Plus weight management program.

Obesity

03-06-2019 | Diet | DUKPC 2019 | News

Diabetes remission durable for a third of DiRECT participants

Just over a third of people who undertook a period on a very-low-calorie diet in the DiRECT trial to tackle type 2 diabetes are in remission 24 months later, the investigators have reported.

03-23-2018 | Lifestyle interventions | News

Weight loss intervention may reduce proportion of life spent disabled in type 2 diabetes

Analysis of data from the Look AHEAD trial suggests that a long-term intensive lifestyle intervention could delay the onset of physical disability among overweight and obese patients with type 2 diabetes.

03-20-2018 | Diet | News

DiRECT: Effects on insulin and liver fat revealed

Researchers from the DiRECT trial have reported large positive effects on liver fat and insulin secretion among people who achieved type 2 diabetes remission in response to a very-low-calorie diet.

Man demonstrating weight loss (symbolic image with model)

12-05-2017 | Diet | News

DiRECT trial: Diabetes remission achievable in primary care

Nearly half of the patients helped to follow a very-low-calorie diet for at least 3 months achieved and maintained remission of type 2 diabetes over the 12 months of the DiRECT trial, the investigators report.

11-06-2017 | Prediabetes | News

Lifestyle interventions have most staying power for diabetes prevention

A meta-analysis shows that although medications and lifestyle changes can both reduce the risk for type 2 diabetes in high-risk patients, only lifestyle modifications have a sustained effect.

07-20-2017 | Cardiovascular outcomes | News

Machine learning hints at complex treatment effects in Look AHEAD

A machine-learning analysis suggests the existence of heterogeneous treatment effects in the Look AHEAD trial, which could account for the overall neutral effect of the study intervention on cardiovascular outcomes.

Weight loss

02-23-2017 | Liraglutide (obesity) | News

Liraglutide boosts preventive power of lifestyle intervention in prediabetes

Liraglutide enhances the positive effects of lifestyle intervention on weight loss and glycemic control in patients with prediabetes, show the 3-year outcomes of the SCALE Obesity and Prediabetes trial.

09-02-2016 | Obesity | News | Article

Weight loss influences ‘hard’ CVD endpoints in diabetes

A post-hoc analysis of the Look AHEAD trial suggests that weight loss can avert cardiovascular disease events in overweight patients with Type 2 diabetes.