Insulin degludec/aspart (IDegAsp) is the first soluble insulin co-formulation, combining a long-acting insulin degludec (IDeg) and rapid-acting insulin aspart (IAsp). In type 2 diabetes patients with oral antidiabetes agent (OAD) inadequacy, insulin initiation with IDegAsp once daily provides superior long-term glycemic control compared to insulin glargine, with similar fasting plasma glucose (FPG) and insulin doses, and numerically lower rates of overall and nocturnal hypoglycemia. Furthermore, in patients with uncontrolled type 2 diabetes previously treated with insulins, IDegAsp twice daily effectively improves glycated hemoglobin and FPG, with fewer hypoglycemic episodes versus premix insulins and basal bolus therapy. In patients with type 1 diabetes mellitus, IDegAsp once daily with two doses of IAsp is a convenient, yet effective, regimen as compared to the conventional 4–5 injection-based basal bolus therapy. IDegAsp is an appropriate and reasonable option for initiation of insulin therapy in both type 1 and type 2 diabetes.
COMUNICADO: Ryzodeg ® Significantly reduces the risk of low blood sugar in people with type 2 diabetes who fast during Ramadan. http://www.europapress.es/comunicados/internacional-00907/noticia-comunicado-ryzodeg-significantly-reduces-the-risk-of-low-blood-sugar-in-people-with-type-diabetes-who-fast-during-ramadan-20171207094659.html. Accessed 12 Feb 2018.
Ryzodeg ® Summary of product characteristics 2015. http://www.ema.europa.eu/docs/en_GB/document...Product.../WC500139011.pdf. Accessed 16 May 2018
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