Skip to main content
Top

08-17-2018 | Insulin pumps | Review | Article

An Overview of Safety Issues on Use of Insulin Pumps and Continuous Glucose Monitoring Systems in the Hospital

Journal: Current Diabetes Reports

Authors: Bithika Thompson, Melinda Leighton, Mary Korytkowski, Curtiss B. Cook

Publisher: Springer US

Abstract

Purpose of Review

Summarize safety issues related to patients using insulin pump therapy and continuous glucose monitoring systems (CGMS) in the outpatient setting when they are hospitalized and to review steps that can be taken to mitigate risk associated with use or discontinuation of these devices.

Recent Findings

Two recent consensus conferences were held on the topics of inpatient use of insulin pumps and CGMS devices. In addition to commonly known safety issues (e.g., device malfunction, infection), cybersecurity and the vulnerability of contemporary technology to hacking have emerged. CGMS capabilities offer the promise of advancing the goal for development of glucometry (centralized monitoring of real-time glucose data). Strategies to assuring safe use of insulin pumps and CGMS in the hospital include collaboration between the patient and staff, proper patient selection, and clear policies and procedures outlining safe use. Available data indicates few adverse events associated with these devices in the hospital.

Summary

Current data suggests, with proper patient selection and a clear process in place for glycemic management, that adverse events are rare, and consensus favors allowing use of the technology in the hospital. The topic of insulin pump and CGMS in the hospital would greatly benefit from more institutions reporting on their experiences and prospective clinical trials.
Literature
1.
Anonymous. North America insulin pump market prospect, share, development, growth, and demand forecast to 2022. Research and Markets. 2017. Available at:https://​www.​researchandmarke​ts.​com/​research/​qnp7d9/​north_​america. Accessed 12 March 2018.
2.
Wong JC, Foster NC, Maahs DM, Raghinaru D, Bergenstal RM, Ahmann AJ, et al. Real-time continuous glucose monitoring among participants in the t1d exchange clinic registry. Diabetes Care. 2014;37:2702–9.CrossRefPubMedCentralPubMed
3.
Anonymous. United states $5 billion insulin pump markets, 2022. PR Newswire 2017. Available at https//www.​prnewswire.​com/​news-releases/​united-states-5-billion-insulin-pump-markets-2022-300507594.​html. Accessed 12 March 2018.
4.
•• Thompson B, Korytkowski M, Klonoff D, Cook C. Consensus statement on use of continuous subcutaneous insulin infusion therapy in the hospital. J Diabetes Sci Technol. 2018;12(4):880–9. https://​doi.​org/​10.​1177/​1932296818769933​. This consensus statement provides a thorough overview of continuous subcutaneous insulin infusion therapy in the hospital. This consensus statement summarizes expert opinion for use of continuous insulin infusion in the hospital.CrossRefPubMedPubMedCentral
5.
Medtronic. Minimed 670g insulin pump system. Available at: https://​www.​Medtronicdiabete​scom/​products/​minimed-670g-insulin-pump-system. Accessed 13 March 2018.
6.
Heinemann L, Fleming A, Petrie J, Holl R, Bergenstal R, Peters A. Insulin pump risks and benefits: A clinical appraisal of pump safety standards, adverse event reporting, and research needs. Diabetes Care. 2015;38:716–22.CrossRefPubMed
7.
•• Wallia A, Umpierrez GE, Rushakoff RJ, Klonoff DC, Rubin DJ, Hill Golden S, et al. Consensus statement on inpatient use of continuous glucose monitoring. J Diabetes Sci Technol. 2017;11:1036–44. This consensus statement provides a thorough overview of continuous glucose monitoring in the hospital. This consensus statement summarizes expert opinion for inpatient use of continuous glucose monitoring.CrossRefPubMedCentralPubMed
8.
Thompson BM, Mackey PA, Cook B. “Management of Insulin Pumps in Hospitalized Patients.” In Endocrine and Metabolic Medical Emergencies: A Clinician’s Guide, Second Edition. Ed. Glenn Matfin. 2018 John Wiley &Sons Ltd. pp 571–583.
9.
Zhang Y, Jones Paul L, Klonoff DC. Second insulin pump safety meeting: Summary report. J Diabetes Sci Technol. 2010;4:488–93.CrossRefPubMedCentralPubMed
10.
Klonoff DC, Reyes JS. Insulin pump safety meeting: summary report. J Diabetes Sci Technol. 2009;3:396–402.CrossRefPubMedCentralPubMed
11.
Dungan KM, Han W, Miele A, Zeidan T, Weiland K. Determinants of the accuracy of continuous glucose monitoring in non-critically ill patients with heart failure or severe hyperglycemia. J Diabetes Sci Technol. 2012;6:884–91.CrossRefPubMedCentralPubMed
12.
Pfutzner A, Sachsenheimer D, Grenningloh M, Heschel M, Walther-Johannesen L, Gharabli R, et al. Using insulin infusion sets in CSII for longer than the recommended usage time leads to a high risk for adverse events: results from a prospective randomized crossover study. J Diabetes Sci Technol. 2015;9:1292–8.CrossRefPubMedCentralPubMed
13.
Kannan S, Satra A, Calogeras E, Lock P, Lansang MC. Insulin pump patient characteristics and glucose control in the hospitalized setting. J Diabetes Sci Technol. 2014;8:473–8.CrossRefPubMedCentralPubMed
14.
Klonoff DC. Cybersecurity for connected diabetes devices. J Diabetes Sci Technol. 2015;9:1143–7.CrossRefPubMedCentralPubMed
15.
Armstrong DG, Kleidermacher DN, Klonoff DC, Slepian MJ. Cybersecurity regulation of wireless devices for performance and assurance in the age of "medjacking". J Diabetes Sci Technol. 2015;10:435–8.CrossRefPubMedCentralPubMed
16.
Klonoff D, Kleidermacher DN. Now is the time for a cybersecurity standard for connected diabetes devices. J Diabetes Sci Technol. 2016;10:623–6.CrossRefPubMedCentralPubMed
17.
Goodin D. Insulin pump hack delivers fatal dosage over the air. 2011. Available at: https://​www.​theregister.​co.​uk/​2011/​10/​27/​fatal insulin pump attack/. Accessed 14 April 2018.
18.
Finkle J. J&J warns diabetic patients: insulin pump vulnerable to hacking. 2016. Available at https://​www.​reuters.​com/​article/​us-johnson-johnson-cyber-insulin-pumps-e. Accessed 14 April 2018.
19.
Cook CBBK, Seifert KM, Boyle ME, Mackey P, Castro JC. Transitioning insulin pump therapy from the outpatient to the inpatient setting: a review of 6 years' experience with 253 cases. J Diabetes Sci Technol. 2012;6:995–1002.CrossRefPubMedCentralPubMed
20.
Noschese ML, DiNardo MM, Donihi AC, Gibson JM, Koerbel GL, Saul M, et al. Patient outcomes after implementation of a protocol for inpatient insulin pump therapy. Endocr Pract. 2009;15:415–24.CrossRefPubMed
21.
Faulds ER, Wyne KL, Buschur EO, McDaniel J, Dungan K. Insulin pump malfunction during hospitalization: two case reports. Diabetes Technol Ther. 2016;18:399–403.CrossRefPubMed
22.
Gomez AM, Umpierrez GE, Munoz OM, Herrera F, Rubio C, Aschner P, et al. Continuous glucose monitoring versus capillary point-of-care testing for inpatient glycemic control in type 2 diabetes patients hospitalized in the general ward and treated with a basal bolus insulin regimen. J Diabetes Sci Technol. 2015;10:325–9.CrossRefPubMedCentralPubMed
23.
Chamberlain JJ, Dopita D, Gilgen E, Neuman A. Impact of frequent and persistent use of continuous glucose monitoring (cgm) on hypoglycemia fear, frequency of emergency medical treatment, and smbg frequency after one year. J Diabetes Sci Technol. 2016;10:383–8.CrossRef
24.
Polonsky WH, Peters AL, Hessler D. The impact of real-time contiuous glucose monitoring in patients 65 years and older. J Diabetes Sci Technol. 2016;10:892–7.CrossRefPubMedCentralPubMed
25.
Thomas F, Signal M, Harris DL. Continuous glucose monitoring in newborn infants: how do errors in calibration measurements affect detected hypoglycemia. J Diabetes Sci Technol. 2014;8:543–50.CrossRefPubMedCentralPubMed
26.
Elias S, David L, Tariq S, Lakshmi S, Lillian P, John S, et al. The effect of continuous glucose monitoring in preventing inpatient hypoglycemia in general wards: the glucose telemetry system. J Diabetes Sci Technol. 2018;12:20–5.CrossRef

Be confident that your patient care is up to date

Medicine Matters is being incorporated into Springer Medicine, our new medical education platform. 

Alongside the news coverage and expert commentary you have come to expect from Medicine Matters diabetes, Springer Medicine's complimentary membership also provides access to articles from renowned journals and a broad range of Continuing Medical Education programs. Create your free account »