Microvascular disease a marker of heart failure risk in type 2 diabetes
medwireNews: The presence of microvascular disease in people with type 2 diabetes signals a high risk for heart failure (HF), report the EMPA-REG OUTCOME investigators.
Among placebo-treated participants, those with pre-existing microvascular disease had a significant 1.63-fold increase in the risk for being hospitalized with HF. The risk increase rose with a higher number of microvascular diseases, from 1.34-fold for people with one form of microvascular disease (retinopathy, neuropathy, or nephropathy) to 3.88-fold for those with all three forms.
In all, 48.7% of the 7020 EMPA-REG OUTCOME trial participants had pre-existing microvascular disease. The association with HF risk “has hitherto been underappreciated,” write Subodh Verma (University of Toronto, Ontario, Canada) and team in the Journal of the American College of Cardiology.
Microvascular disease was not significantly associated with major adverse cardiovascular event risk, although there was a trend toward an increased risk with a greater number of microvascular disease types.
The findings “add to the limited prospective data on the impact of microvascular disease on cardiovascular and HF outcomes” in people with type 2 diabetes, say the researchers.
They presented the data at the American College of Cardiology 68th Annual Scientific Session in New Orleans, Louisiana.
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