Skip to main content

06-23-2018 | Gestational diabetes | Article

Maternal gestational diabetes mellitus and the risk of subsequent pediatric cardiovascular diseases of the offspring: a population-based cohort study with up to 18 years of follow up

Acta Diabetologica

Authors: Noa Leybovitz-Haleluya, Tamar Wainstock, Daniella Landau, Eyal Sheiner

Publisher: Springer Milan



The prevalence of gestational diabetes mellitus (GDM) has been increasing worldwide. We aimed to study the effect of GDM on the risk for childhood cardiovascular morbidity of the offspring.


A population-based cohort analysis was performed comparing total and different subtypes of cardiovascular related pediatric diagnoses among offspring of mothers with GDM vs. offspring of mothers with no diabetes. The analysis included all singletons born between the years 1991–2014. Cardiovascular related morbidities included hospitalizations involving a pre-defined set of ICD-9 codes. Mothers with pregestational diabetes, Infants with congenital malformations, multiple gestations, and perinatal deaths were excluded from the analysis. A Cox proportional hazards model was constructed to adjust for confounders.


The study population included 216197 newborns which met the inclusion criteria; among them 4.4% (9460) were born to mothers with GDM controlled by diet and exercise (GDM A1) and 0.3% (724) were born to mothers with GDM requiring oral treatment or insulin (GDM A2). A significant association was noted between GDM and the rate of cardiovascular related hospitalizations (0.97 for GDM A2 vs. 0.57 for GDM A1 vs. 0.33 for no GDM, respectively; p < 0.001). The association remained significant and independent for GDM A1 only while adjusting for relevant confounders [adjusted HR = 1.6 (1.2–2.2); p value 0.001].


A significant association is noted between the GDM and the rate of cardiovascular hospitalizations of the offspring. However, in our population GDM A1 is an independent risk factor for pediatric cardiovascular morbidity of the offspring.

ESC Congress 2021 coverage

27 – 30 August: Browse all of the latest coverage

Addressing suicide risk in diabetes

07-14-2021 | Mental health | Feature | Article

Suicide in diabetes: An important but under-recorded problem

How frequent are suicide deaths in people with diabetes, and can the data be trusted?

07-14-2021 | Mental health | Feature | Article

Risk for suicidal ideation: Who, when, and why?

What makes some people more likely than others to have suicidal thoughts? We outline the risk factors and circumstances that can play a role.

07-14-2021 | Mental health | Feature | Article

Creating a safety net: How doctors can help suicidal patients

Screening, emergency protocols, and person-centered care – just some of the ways healthcare professionals can identify and support people at increased risk for suicide. Click through for more.

Suicide risk in diabetes: Why doctors may hesitate to screen, but should not