‘Exceedingly high’ vascular event risk with type 2 diabetes plus PAD
medwireNews: The risk for major adverse cardiovascular events (MACE) in people with type 2 diabetes plus peripheral artery disease (PAD) exceeds even that of those with coronary artery disease (CAD), researchers report.
Their study showed that type 2 diabetes and PAD were associated with an increased MACE risk relative to CAD on its own.
But the highest rate overall was observed in study participants who had both type 2 diabetes and PAD, making this combination “exceedingly high risk,” said Christoph Saely (Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria), who presented the findings at the virtual ESC Congress 2021.
The researchers prospectively monitored 923 people with stable CAD, including 26.7% who also had type 2 diabetes, and 292 with PAD, including 42.1% with diabetes.
Over an average of 10 years, the highest MACE rate was observed in people with both type 2 diabetes and PAD, at 47.2%, and the lowest in those with CAD but no diabetes, at 25.1%. People with CAD plus diabetes and those with PAD without diabetes h
ad intermediate rates that did not significantly differ from each other, at 35.4% and 30.2%, respectively.
After accounting for baseline variables, having PAD was associated with a significant 46% increased risk for MACE, relative to having CAD. And having type 2 diabetes was associated with an additional 58% increase in risk.
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