Type 1 diabetes

Women with type 1 diabetes who have microalbuminuria at the time of pregnancy have an increased risk for adverse pregnancy outcomes in the short term and for diabetes complications in the long term, shows research.

Starting people on bevacizumab and switching to aflibercept only when necessary keeps costs down without compromising treatment efficacy for people with diabetic macular edema, shows a randomized trial.

The dual Ang-2 and VEGF-A pathway inhibitor faricimab is noninferior to aflibercept for improving visual acuity in people with diabetic macular edema, and an individualized dosing strategy could help reduce treatment burden, suggest findings from the YOSEMITE and RHINE trials.

Among pregnant women with preexisting diabetes, those with nephropathy or retinopathy may be at increased risk for pregnancy complications, suggest findings from a systematic review and meta-analysis.

African–Caribbean ethnicity may be a predisposing factor for sight-threatening diabetic retinopathy in people with type 1 diabetes, research suggests.

People with type 1 diabetes using an insulin pump might have a reduced risk for diabetic retinopathy progression compared with those on multiple daily injections, suggest results from a Scottish observational study.

Any amount of residual C-peptide is protective against some type 1 diabetes complications, show findings from a large, population-based study.

Intravitreous aflibercept and vitrectomy with panretinal laser photocoagulation appear to have similar efficacy over 24 weeks when used for the treatment of vitreous hemorrhage from proliferative diabetic retinopathy, researchers report.

Results from a UK retrospective study suggest that there is “considerable variation” in diabetic eye screening attendance in different age groups, with the worse attendance rates among younger people.

Aiming for the lowest international targets in glycated hemoglobin levels may not protect against retinopathy and nephropathy in patients with type 1 diabetes, research suggests.

An offline, smartphone-based, nonmydriatic retinal imaging system accurately detects referable diabetic retinopathy when used by minimally trained operators in a point of care setting, show data from a pilot study carried out in India.

A retrospective analysis of clinical trial data indicates that regular eye examinations may not always be necessary for people younger than 18 years of age with type 1 diabetes, despite current recommendations to the contrary.

Research published in JAMA shows similar outcomes for patients with center-involved diabetic macular edema and good visual acuity over the first 2 years after diagnosis, regardless of whether they are managed with aflibercept, laser photocoagulation, or observation.

All-cause mortality risk in patients with type 1 diabetes and more than one microvascular complication does not exceed the combined risk estimates of each separate complication, Danish researchers report.

A population-based study suggests that treatment with a statin may slow the risk for new and worsening retinopathy in patients with diabetes and dyslipidemia.

Patients with type 1 diabetes may develop multiple complications even before they reach adulthood, shows an analysis of the SEARCH for Diabetes in Youth Study.

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Cai X et al. Endocrine 2018. doi: 10.1007/s12020-018-1697-y

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Sabanayagam C et al. Lancet Diabetes Endocrinol 2018. doi: 10.1016/S2213-8587(18)30128-1