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Sulfonylureas 

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  1. 24-04-2023 | Sulfonylureas | News | Article

    Sulfonylureas ‘unlikely’ to increase CV, mortality risk in real-world use

    Findings from a Scottish national cohort study show that the use of sulfonylureas as second-line glucose-lowering therapy is not associated with elevated cardiovascular risk or all-cause mortality.

  2. play
    28-10-2021 | Sulfonylureas | Conference coverage | Video

    SAFES summit 2021: Using modern sulfonylureas

    Mohammad Wali Naseri outlines best practice for use of modern sulfonylureas in people with type 2 diabetes, as presented at the 2021 South Asian Federation for Endocrine Societies summit.

  3. 30-07-2021 | SGLT2 inhibitors | News | Article

    SGLT2 inhibitors linked to lower mortality rate than sulfonylureas in clinical practice

    Use of SGLT2 inhibitors rather than sulfonylureas as an addition to metformin therapy may be associated with a reduced mortality risk for people with type 2 diabetes, suggest real-world study findings.

  4. 01-03-2021 | Older adults | News | Article

    Sulfonylureas, insulin linked to increased hypoglycemia risk in older people with type 2 diabetes

    Writing in Diabetes Care , the authors conclude: “In view of the increasing prevalence of multimorbid, older patients with type 2 diabetes, and the prognostic role of insulin and sulfonylureas, further research is warranted to explore the net clinical benefit of deintensification by replacement of these treatments with other glucose-lowering medications in these patients.” medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2021 Springer Healthcare Ltd, part of the Springer Nature Group Diabetes Care 2021; doi:10.2337/dc20-0876

  5. 22-05-2019 | Sulfonylureas | Editorial | Article

    The CAROLINA trial: Make or break for sulfonylureas?

    Diabetologist Sanjay Kalra puts the CAROLINA trial into historical context and considers the present-day implications for the use of DPP-4 inhibitors and sulfonylureas.

  6. 24-10-2017 | Sulfonylureas | News | Article

    First-line sulfonylureas may increase hypoglycemia risk in type 2 diabetes

    Patients initiating treatment for type 2 diabetes with sulfonylureas are more than four times as likely to be hospitalized with hypoglycemia as those treated with metformin, population-based study data show.

  7. 24-05-2018 | Gliclazide | Review | Article

    The place of gliclazide MR in the evolving type 2 diabetes landscape: A comparison with other sulfonylureas and newer oral antihyperglycemic agents

    Colagiuri S et al. Diabetes Res Clin Prac 2018. doi: 10.1016/j.diabres.2018.05.028

  8. 04-06-2018 | Neonatal diabetes | Article

    Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: An international cohort study

    Bowman P et al. Lancet Diabetes Endocrinol 2018. doi: 10.1016/S2213-8587(18)30106-2

  9. 31-08-2023 | Type 2 diabetes | News | Article

    Pragmatic trial suggests best cardioprotective agents for type 2 diabetes

    The absolute risk reductions compared with sulfonylureas per 1000 person–years were 12.34 with SGLT2 inhibitors and 12.07 with GLP-1 receptor agonists.

  10. 22-09-2022 | EASD 2022 | News | Article

    Model could predict severe hypoglycemia risk in people with type 2 diabetes

    A number of factors are associated with severe hypoglycemia risk in people with type 2 diabetes treated with insulin or sulfonylureas, suggests research reported at the 58th EASD Annual Meeting in Stockholm, Sweden.

  11. 01-09-2022 | Metformin | News | Article

    People with type 2 diabetes and CKD missing out on renoprotective drugs

    SGLT2 inhibitor use increased from 0.5% to 9.4%, while the use of sulfonylureas increased from a baseline of around 27% to approximately 34% in 2008 then decreased and stabilized at around 20%.

  12. 14-10-2022 | Dementia | News | Article

    Glitazone use linked to reduced dementia risk in type 2 diabetes

    The rate ranged from 6.2 cases per 1000 person–years in people taking metformin monotherapy to 13.4 per 1000 person–years in those taking TZDs and sulfonylureas in combination.

  13. 05-05-2023 | Insulin icodec | News | Article

    ONWARDS 2: Weekly insulin icodec superior to degludec in type 2 diabetes

    Participants taking sulfonylureas (22%) or glinides (4%) discontinued these medications to reduce the risk for hypoglycemia.

  14. 07-06-2022 | ADA 2022 | News | Article

    Case series suggests SGLT2 inhibitors could be useful add-on therapy for MODY3

    Beta cell function does not normally deteriorate in these cases and the condition can be managed with oral diabetes drugs such as sulfonylureas.

  15. 04-08-2022 | Tirzepatide | News | Article

    SURPASS J trials support tirzepatide use in Japanese people with type 2 diabetes

    This “is particularly notable as sulfonylureas and thiazolidinediones are generally associated with weight gain,” remark Chin et al.

  16. 29-03-2022 | Metformin | News | Article

    Paternal metformin exposure linked to increased birth defect risk

    That associated with sulfonylureas was a nonsignificant 1.34, whereas there was no sign of an association with insulin use.

  17. 13-12-2022 | Diet | News | Article

    Low-carb, high-fat diet gives glycemic benefits in randomized trial

    “The 9.5 mmol/mol (0.88%) reduction in HbA1c in participants on the LCHF diet is similar to many antidiabetic medications, such as dipeptidyl peptidase-4 antagonists, sodium–glucose cotransporter-2 antagonists, and sulfonylureas,” write the researchers in the Annals of Internal Medicine .

  18. 17-12-2021 | Heart failure | News | Article

    Metformin, but not sulfonylurea, may reduce poor outcome risk post HHF

    They add that sulfonylureas “may best be avoided” in people with HF and diabetes, while further randomized clinical trials are needed to confirm the benefit of metformin in individuals with HFpEF. medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2021 Springer Healthcare Ltd, part of the Springer Nature Group JACC Heart Fail 2021; doi:10.1016/j.jchf.2021.11.001

  19. 31-03-2022 | Diet | Hot topic review | Article

    Fasting and people with diabetes

    This includes: No action (eg, for metformin and weekly glucagon-like peptide-1 receptor agonists); Skip the dose to reduce costs (eg, for dipeptidyl peptidase 4 inhibitors and SGLT2 inhibitors); Reduce or omit to avoid hypoglycemia (eg, for sulfonylureas and basal/prandial/combination insulins).

  20. 26-10-2021 | Type 2 diabetes | Conference report | Article

    Conference report: SAFES summit 2021

    October 2, 2021: Kathmandu, Nepal

    SAFES summit 2021: Using modern sulfonylureas The SAFES summit also addressed various therapeutic options for the management of diabetes.

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