A pooled analysis of the DAPA-HF and DAPA-CKD trials suggests that taking the SGLT2 inhibitor dapagliflozin reduced the participants’ risk for developing type 2 diabetes by around a third.

Reducing blood pressure may be an effective strategy for the prevention of new-onset type 2 diabetes, suggest researchers from the Blood Pressure Lowering Treatment Trialists’ Collaboration.

The latest DAPA-CKD data show the large absolute benefits of dapagliflozin treatment in people with peripheral artery disease or atrial fibrillation, and that the medication may reduce the risk for type 2 diabetes in people with initial prediabetes.

The influence metabolic factors have on type 2 diabetes risk falls as people get older, whereas lifestyle factors convey a greater risk with age, show data from a large, prospective cohort in China.

A randomized trial indicates that testosterone treatment among men with prediabetes or newly diagnosed type 2 diabetes significantly reduces the risk for them having type 2 diabetes 2 years later.

Lifestyle intervention significantly reduces the risk for type 2 diabetes in people who have prediabetes based on fasting plasma glucose or glycated hemoglobin measurements, show findings from a randomized trial.

Focusing efforts on convincing people to return after the first session of the US National Diabetes Prevention Program lifestyle change program, and after the transition to less frequent sessions, may help to optimize program retention, say researchers.

The effectiveness of interventions to increase objectively measured physical activity in people at high risk for developing type 2 diabetes declines in line with symptoms of depression within the normal range, say researchers.

High-dose vitamin D supplementation does not significantly reduce the risk for developing type 2 diabetes among people with prediabetes, show D2d trial data.

The latest update from the UK’s National Health Service Diabetes Prevention Programme shows that persistence pays, and reveals weight loss and a reduction in glycated hemoglobin levels for people who have so far completed the intervention.

Individuals who maintain a blood glucose level below the diabetes threshold during middle age have a lower risk for cardiovascular disease than those who convert to diabetes during this time, observational study data show.

By Eleanor McDermid medwireNews is an independent medical news service provided by Springer Healthcare. © 2018 Springer Healthcare part of the Springer Nature group See also: DiRECT trial: Diabetes remission achievable in primary care Lifestyle interventions have most staying power for diabetes prevention Teaming up with commercial weight management providers aids type 2 diabetes prevention Study highlights power of weight maintenance in diabetes prevention

The ASCEND Study Collaborative Group. N Eng J Med 2018. doi:  10.1056/NEJMoa1804988

Jiang L et al. Diabetes Care 2018; 41: 1462–1470. doi: 10.2337/dc17-2685

A meta-analysis shows that although medications and lifestyle changes can both reduce the risk for type 2 diabetes in high-risk patients, only lifestyle modifications have a sustained effect.