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Clinical trial

12-10-2021 | Diet | News

DiRECT insights highlight ‘ongoing struggle’ of maintaining weight loss

Many participants of DiRECT found reintroduction of food and subsequent weight-loss maintenance to be more challenging than the 800 calorie total meal replacement phase, the investigators report.

29-09-2021 | EASD 2021 | Conference coverage | News

Intra-organ fat reduction parallels type 2 diabetes remission in lean people

Outwardly lean people who have type 2 diabetes have increased intra-organ fat, reductions in which occur in line with weight loss-induced diabetes remission, say researchers.

26-07-2021 | Glycemic control | News

Delayed impact of high glucose levels may explain legacy effect

The so-called legacy effect of a period of good glycemic control in type 2 diabetes may be because the greatest impact of hyperglycemia occurs many years in the future, show data from the UKPDS.

31-05-2021 | Hypertension | News

DiRECT analysis supports antihypertensive withdrawal before very-low-calorie diet

Blood pressure falls markedly when people with type 2 diabetes undertake a very-low-calorie diet, and immediate withdrawal of antihypertensive medications has few ill effects, say the DiRECT investigators.

29-04-2021 | DUKPC 2021 | Conference coverage | News

Liver, pancreatic fat may underlie ‘disproportionately raised’ CV risk in women with diabetes

Women naturally have lower levels of hepatic and pancreatic fat than men, but having type 2 diabetes removes this advantage and confers a relatively larger increase in cardiovascular risk, show further data from DiRECT.

Weight gain

12-01-2021 | Diet | News

Ghrelin changes predict weight regain after DiRECT diet

Ghrelin is the only appetite-related hormone that predicted weight regain among the participants of the DiRECT trial, say the researchers.

09-10-2020 | Diet | News

Pancreatic morphology normalizes with sustained type 2 diabetes remission

Sustained remission of type 2 diabetes in DiRECT was accompanied by normalization of pancreatic morphology, say the researchers.

09-09-2020 | Diet | News

Weight loss strongest predictor of remission in DiRECT

The strongest predictor of type 2 diabetes remission is weight loss, with other variables only modestly associated with outcome and insufficient to identify people unsuitable for attempting this goal, shows a post-hoc analysis of DiRECT data.