After around 1500 person–years of follow up, almost all participants experienced self-limiting mild-to-moderate adverse effects (AEs) of grade 1 or 2 (mainly during or immediately after the dosing period), including lymphopenia, rash, or headache.

SGLT2 inhibitors and GLP-1 receptor agonists appear to offer the best protection against major adverse cardiovascular events in people with type 2 diabetes.

Skin reactions to glucose monitors and insulin pumps occur in more than a quarter of users but only occasionally result in device discontinuation, research shows.

Specialist nurse Nicola Milne discusses the side effects that can arise in people with type 2 diabetes during initiation of GLP-1 receptor agonists, and how to best manage them.

People taking dipeptidyl peptidase-4 inhibitors to treat type 2 diabetes may have an increased risk for cholecystitis, especially with longer duration of treatment, show findings of a meta-analysis.

Researchers have identified four simple clinical criteria that can be used to predict the likelihood of insulin allergy and guide decisions about the need for confirmatory allergy testing.

“Important in this guidance will be communicating that the adverse relationship was specific to metformin during the period of spermatogenesis,” she says. medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2022 Springer Healthcare Ltd, part of the Springer Nature Group Ann Intern Med 2022; doi:10.7326/M21-4389 Ann Intern Med 2022; doi:10.7326/M22-0770

Hyperglycemia is a common adverse effect of high-dose corticosteroids, and can manifest as worsening glucose control in people with known diabetes and development of hyperglycemia in those without a history of diabetes.

Illustrating this point, rosiglitazone, which had no particular safety issues when used in children in the TODAY study, later became mired in controversy and partially withdrawn from the market after a meta-analysis of data in adults raised concerns of adverse cardiovascular side effects.

There were no adverse events attributed to the app use and no adverse device effects were observed.

However, GLP-1 receptor agonist treatment significantly reduced the risk for major adverse cardiovascular events regardless of whether the participants had heart failure, with 15% and 12% reductions in those with and without a history of heart failure, respectively.

Buckingham and team observed no serious adverse device effects, unanticipated adverse device effects, or diabetic ketoacidosis events during a total of 3041 device wears.

A systematic review and meta-analysis, which adjusted for confounding factors, has shown that gestational diabetes is associated with a range of adverse pregnancy outcomes that vary according to insulin use.

“Importantly, the effects of canagliflozin on hyperkalaemia outcomes did not appear to be explained by the differential concomitant use of potassium-sparing diuretics or mineralocorticoid receptor antagonists during the trial, which were similar in both treatment arms,” write Heerspink and co-authors in the European Heart Journal .

New users of SGLT2 inhibitors are more likely to develop retinal vein occlusion than those initiating other glucose-lowering drugs, suggest results from a South Korean study.

Having diabetes exacerbates the adverse effects of extreme temperatures on people’s risk for having an acute myocardial infarction, say researchers.

Analysis of the Health and Retirement Study indicates that the adverse effects of earlier age of type 2 diabetes onset are also evident in an older population.

Secondary analysis of the PARADIGM-HF trial shows that the adverse effects of diabetes on kidney function can be ameliorated by a neprilysin inhibitor.

The small proportion of people who experience an eGFR fall of more than 30% on starting an SGLT2 inhibitor may be at increased risk for adverse outcomes, research suggests.