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Semaglutide for weight loss

Results from the STEP and SELECT trials

What you need to know

The weekly injectable GLP-1 receptor agonist semaglutide is approved for use in type 2 diabetes at a dose optimized for glucose lowering, of 1.0 mg/week. But the results of the first STEP trial show that at a higher dose of 2.4 mg/week it is also an effective weight loss agent, easily surpassing the effects of any currently available medication.

Browse this page for details of the completed and ongoing STEP trials, and the SELECT cardiovascular outcomes study, plus interviews with the researchers.

At a glance

A quick guide to the STEP trials

Read our round-up of the STEP phase 3 trials of semaglutide 2.4 mg in people with obesity, plus the SELECT cardiovascular outcomes trial.

View the quick guide here

STEP 1 trial results

STEP 2 trial results

STEP 3 trial results

STEP 4 trial results

STEP 5 trial results

Doctor measures a man's waist

10-10-2022 | Semaglutide | News

STEP 5: Sustained semaglutide treatment maintains weight loss

The substantial weight loss achieved with weekly semaglutide 2.4 mg is maintained if people continue to take the medication for 2 years, show the STEP 5 results.

STEP 6 trial results

Doctor measuring blood pressure of senior woman at home

07-02-2022 | Semaglutide | News

STEP 6: Semaglutide addresses ‘pathophysiology of metabolic syndrome’ in east Asians

The STEP 6 findings reveal significant weight loss, along with a reduction in abdominal visceral fat, in east Asian people with obesity taking a high dose of semaglutide.

STEP 8 trial results

Diabetes medication in overweight person

11-01-2022 | Semaglutide | News

STEP 8: Semaglutide better than liraglutide at weight-management doses

Semaglutide 2.4 mg produces substantially more weight loss than liraglutide 3.0 mg in people with overweight or obesity but without diabetes, say the STEP 8 investigators.


FDA approves higher semaglutide dose for obesity

June 5, 2021: The US FDA has approved the 2.4 mg weekly dose of semaglutide to treat obesity regardless of the presence of type 2 diabetes.

Read more

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