Obesity

Researchers report that metabolic abnormalities begin to increase at levels of liver fat commonly regarded as normal.

The publication of two SURPASS-3 substudies in The Lancet Diabetes & Endocrinology reveals significant benefits of tirzepatide on liver and abdominal fat in people with type 2 diabetes, as well as on time in target glucose range.

Read this Hot Topic Review to catch up on the latest research into the risks and benefits of fasting for people with diabetes.

Obesity is as prevalent in people with type 1 diabetes as in the general US population and the age-adjusted chronic kidney disease rate is higher than in people with type 2 diabetes, report researchers.

Gastric bypass and sleeve gastrectomy both result in “almost complete clearance of liver fat” within a year after the intervention, show secondary outcomes of a randomized trial.

Stefan Bornstein provides an overview of the current understanding about COVID-19 and diabetes, including medications, vaccines, and the impact of SARS-CoV-2 infection on diabetic ketoacidosis.

Visceral adipose tissue is strongly indicative of the presence of non-alcoholic fatty liver in people with type 1 diabetes, but fat in other areas is not, show findings from the FinnDiane study.

Metabolic surgery can result in type 2 diabetes remission lasting for at least 10 years, and people who relapse still achieve markedly improved glycemic control, shows follow-up from a randomized trial published in The Lancet.

Researchers have detected moderate or severe liver fibrosis in around one in six people with type 2 diabetes.

Youth with type 2 diabetes have lower areal bone mineral density than those with obesity or who are of normal weight, according to the results of a cross-sectional study.

Weight loss after gastric bypass surgery results in important cardiovascular and renal benefits for obese people with type 2 diabetes, irrespective of their baseline renal function, observational cohort study data show.

Adolescents who undergo bariatric surgery do not as a rule experience resolution of mental health problems, say researchers.

Severely obese people show evidence of impaired cognition even when they have no signs of prediabetes or diabetes, but retinopathy and nephropathy only occur in those with hyperglycemia, US research shows.

Our clinical advisors discuss their EASD 2019 highlights, including new treatment options for children and older adults with type 2 diabetes, the complexities surrounding hypoglycemia prevention, and the implications of the VERIFY trial.

People who undergo bariatric surgery have a lower long-term risk for mortality, but a higher risk for adverse events such as gastrointestinal and nutritional disorders, compared with those who do not undergo surgery, researchers report.

Read the linked commentary from John Wilding

Obstructive sleep apnea syndrome is a common and potentially serious comorbidity in people with diabetes and obesity. John Wilding highlights what you need to know about the condition.

Salas-Salvadó J et al. Diabetes Care 2018: dc180836. doi: 10.2337/dc18-0836

Fisher DP et al. JAMA 2018; 320: 1570–1582. doi: 10.1001/jama.2018.14619

The weight-loss medication lorcaserin neither increases nor reduces cardiovascular risk, report the CAMELLIA–TIMI 61 investigators.

Obese patients with type 2 diabetes who undergo bariatric surgery achieve large reductions in their risk for microvascular complications, shows a real-world study.