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09-06-2022 | Glycemic control | Adis Journal Club | Article

Diabetes Therapy

Glycaemic Control Achieves Sustained Increases of Circulating Endothelial Progenitor Cells in Patients Hospitalized for Decompensated Diabetes: An Observational Study

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Authors: Benedetta Maria Bonora, Roberta Cappellari, Marco Grasso, Marta Mazzucato, Marianna D’Anna, Angelo Avogaro & Gian Paolo Fadini

Abstract 

Background and Aim

Diabetes reduces the levels of circulating endothelial progenitor cells (EPCs), which contribute to vascular homeostasis. In turn, low EPCs levels predict progression of chronic complications. Several studies have shown that hyperglycaemia exerts detrimental effects on EPCs. Improvement in glucose control with glucose-lowering medications is associated with an increase of EPCs, but only after a long time of good glycaemic control. In the present study, we examined the effect of a rapid glycaemic amelioration on EPC levels in subjects hospitalized for decompensated diabetes.

Methods

We used flow cytometry to quantify EPCs (CD34+/CD133+KDR+) in patients hospitalized for/with decompensated diabetes at admission, at discharge, and 2 months after the discharge. During hospitalization, all patients received intensive insulin therapy.

Results

Thirty-nine patients with type 1 or type 2 diabetes were enrolled. Average (± SEM) fasting glucose decreased from 409.2 ± 25.9 mg/dl at admission to 190.4 ± 12.0 mg/dl at discharge and to 169.0 ± 10.3 at 2 months (both p < 0.001). EPCs (per million blood cells) significantly increased from hospital admission (13.1 ± 1.4) to discharge (16.4 ± 1.1; p = 0.022) and remained stable after 2 months (15.5 ± 1.7; p = 0.023 versus baseline). EPCs increased significantly more in participants with newly-diagnosed diabetes than in those with pre-existing diabetes. The increase in EPCs was significant in type 1 but not in type 2 diabetes and in those without chronic complications.

Conclusion

In individuals hospitalized for decompensated diabetes, insulin therapy rapidly increases EPC levels for up to 2 months. EPC defect, reflecting impaired vascular repair capacity, may be reversible in the early diabetes stages.

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Key Summary Points

Why carry out this study?

Endothelial progenitor cells (EPCs) reflect the endogenous regenerative capacity and are reduced in diabetes.

Though diabetes therapy can improve circulating EPC levels, we herein examined the effect of acute glycaemic re-compensation on EPCs.

What was learned from the study?

Despite glycaemic control took months to increase EPC levels in prior studies on outpatients with mildly decompensated diabetes, we found that intensive insulin therapy in people hospitalized with severe hyperglycaemia elicits a rapid and significant increase in EPCs.

The EPC increase was mostly evident in patients with newly diagnosed diabetes and in those without chronic complications.