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The REWIND trial


The REWIND trial was a cardiovascular outcomes trial involving dulaglutide, but was notable for having recruited a majority of people (approximately 70%) who did not have overt cardiovascular disease.

The investigators found a significant reduction in cardiovascular risk, irrespective of whether participants had established cardiovascular disease, suggesting that glucagon-like peptide-1 receptor agonists may be cardioprotective even in patients who have not yet had a clinical event. They also found a significant reduction in the risk for renal outcomes, in an exploratory analysis.

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The REWIND investigators will present data on the effects of dulaglutide on stroke outcomes at 55th EASD Annual Meeting (EASD 2019):

Unique features and findings of the long-term REWIND (Researching cardiovascular Events with a Weekly INcretin in Diabetes) trial 
Thursday, September 19, 12:00–13:00. Vilanova Hall, Fira Barcelona Gran Via, Spain. 
Session Chair: L. Rydén, Sweden

  1. Effect of dulaglutide on serious health outcomes. H. C. Gerstein, Canada
  2. New findings from the REWIND trial. M. C. Riddle, USA

What our Editorial Board said: 

John Wilding discusses how the results of the REWIND study add to our knowledge of the effects of the glucagon-like peptide-1 receptor agonist class in people with varying degrees of cardiovascular risk (3:37).

Back to the EASD 2019 conference hub