The primary findings
The ground-breaking Diabetes Remission Clinical Trial (DiRECT) showed for the first time that substantial weight loss achieved with diet alone in a primary care setting could reverse type 2 diabetes.
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DiRECT: Diabetes remission achievable in primary care
Nearly half of the patients helped to follow a very-low-calorie diet for at least 3 months achieved and maintained remission of type 2 diabetes over the 12 months of the DiRECT intervention, the investigators report.
The 2-year outcomes
The DiRECT investigators followed up the study participants to assess how many remained in remission.
How does the intervention work in routine practice and outside of the UK?
Latest reporting on DiRECT
More research findings from the DiRECT, including mechanisms and cost-effectiveness.
DiRECT trial, Young woman losing weight/© atakan / Getty Images / iStock, Feet on weighing scales, Roy Taylor/© Newcastle University, UK, John Wilding, Amar Puttanna, Alison Barnes, Medicine Matters branded image/© ipopba / Getty Images / iStock, Medicine Matters branded image/© fizkes / Getty Images / iStock