medwireNews: Study findings published in Diabetes, Obesity and Metabolism suggest that the presence of microvascular complications is associated with increased risk for all-cause mortality in people with type 2 diabetes hospitalized for COVID-19.
This suggests these complications play a “deleterious” role in this population and supports a “systematic search for microvascular complications for any patient with diabetes and COVID-19 to identify patients at high mortality risk,” say Samy Hadjadj (Nantes Université, France) and co-authors.
The study analyzed data for 2951 participants from the French CORONADO study, 3387 from the UK ABCD COVID-19 audit, and 9327 from the US AMERICADO study. Microvascular diabetic complications, including retinopathy, kidney disease, and/or history of foot ulcer, were reported in 44.5%, 53.4%, and 79.0% of each group, respectively.
These individuals with any microvascular complication had a corresponding 3.86-, 1.67-, and 1.58-fold higher risk for all-cause mortality versus those without. In particular, the researchers note that the presence of diabetic kidney disease alone was associated with all-cause mortality risk “[i]n a very consistent manner in all 3 study populations,” with significant odds ratios of 2.53, 1.24, and 1.66, respectively.
A meta-analysis of the three studies showed that participants with microvascular complications had a significant 1.50-fold elevated risk for all-cause mortality after adjustment for age, sex, hypertension, and cardiovascular disease.
medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2022 Springer Healthcare Ltd, part of the Springer Nature Group
Diabetes Obes Metab 2022; doi:10.1111/dom.14845
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