The DEFINE-HF trial
DEFINE-HF is a randomized, placebo-controlled trial testing the effects of 12 weeks of treatment with the SGLT2 inhibitor dapagliflozin in patients who have chronic heart failure with reduced systolic function, but do not necessarily have type 2 diabetes.
Lars Rydén discusses how the results of the DAPA-HF and DEFINE-HF trials will impact treatment decisions for patients with heart failure (6:38).
The DEFINE-HF investigators reported the effects of treatment on heart failure-specific biomarkers, symptoms, and functional status at the 55th EASD Annual Meeting (EASD 2019):
Dapagliflozin effects on biomarkers, symptoms and functional status in patients with heart failure and reduced ejection fraction with and or without diabetes: the DEFINE-HF trial
Wednesday, September 17, 13:15–14:15. Vilanova Hall, Fira Barcelona Gran Via, Spain
Session Chair: L. Rydén, Sweden
- Background and rationale for DEFINE-HF trial. M. N. Kosiborod, USA
- DEFINE-HF study design and baseline characteristics. M. E. Nassif, USA
- Effect of dapagaliflozin on the primary outcomes. M. N. Kosiborod, USA
- Effect of dapagliflozin on secondary and safety outcomes. M. E. Nassif, USA
- Putting DEFINE-HF in perspective: clinical implications and path forward. M. N. Kosiborod, USA
What our Editorial Board said:
It feels satisfying to see endocrine drugs being exapted to non-endocrine uses: Perhaps endocrine exaptation is the flavor of the future.