Diabetes complications and comorbidities: Neuropathy

Real-world data from the UK Biobank show the value of a healthy lifestyle in people with type 2 diabetes hoping to avoid microvascular complications.

Study findings suggest that the presence of microvascular complications is associated with increased risk for all-cause mortality in people with type 2 diabetes hospitalized for COVID-19.

Combination therapy with three commonly used medications has achieved similar levels of pain relief for people with diabetic peripheral neuropathic pain in the randomized OPTION-DM trial.

People with diabetes who attend an annual wellness check are significantly less likely to require a major lower extremity amputation within the same year, shows research from the US Diabetes Belt.

Men and women with prediabetes or type 2 diabetes have high levels of sexual dysfunction, shows an analysis of data from the Diabetes Prevention Program Outcomes Study in the USA.

Clinicians are only rarely monitoring vitamin B12 levels in people with type 2 diabetes using metformin, research shows.

People with diabetic foot ulcers who live in areas with a high level of deprivation may be more likely to require major amputation than those living in less deprived areas, suggest findings from a French cohort study.

Providing additional shoes designed for wearing indoors may improve use of custom-made footwear among people with diabetes at high risk for foot ulceration, research suggests.

Early intensive glycemic control may reduce the long-term risk for foot ulcers in people with type 1 diabetes, suggest data from the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications study.

Study results suggest that among people with diabetes, those with a history of foot ulceration are more likely to undergo amputation or die than those without.

Both small and large nerve fiber impairment can be detected among people with well-controlled recent-onset type 1 or type 2 diabetes, and may regress with time, shows German research presented at the virtual 57th EASD Annual Meeting.

Findings from the Hypo-RESOLVE study suggest that exposure to hypoglycemia is associated with subsequent negative clinical outcomes in people with diabetes, supporting a key role for hypoglycemia prevention.

The risk for diabetes-related complications increases over time among people with youth-onset type 2 diabetes, with the majority having at least one microvascular complication by the time of young adulthood, suggest follow-up results from the TODAY study.

The risk for amputations in people with type 1 diabetes is in decline, but high glycated hemoglobin levels and impaired renal function remain important risk factors, say researchers.

Findings from two studies presented at the virtual ADA 81st Scientific Sessions suggest that cardiovascular autonomic neuropathy is associated with an increased risk for kidney function decline and heart failure in people with type 2 diabetes.

People with symptoms indicative of diabetic polyneuropathy near the time of type 2 diabetes diagnosis have a “markedly higher” risk for subsequent cardiovascular disease than those without, researchers report.

Suboptimal medication-taking identified through urine testing is associated with a higher prevalence of microvascular and macrovascular complications in people with type 2 diabetes than found with consistent usage, report researchers.

Randomized trial findings presented at the virtual 56th EASD Annual Meeting suggest that spinal cord stimulation may provide pain relief for people with painful diabetic neuropathy and an inadequate response to conventional treatment.

Cardiovascular autonomic dysfunction in people with longstanding type 1 diabetes “might be a reversible condition,” say researchers who discovered it can be transiently improved with oxygen and breathing exercises.

Negative pressure wound therapy does not improve the closure of chronic diabetic foot wounds compared with current standard treatment in German real-life clinical practice, multicenter trial findings suggest.