Diabetes complications and comorbidities: Ketoacidosis

Data from the DPV cohort show a reduced risk for severe hypoglycemia and diabetic ketoacidosis among children and young people with type 1 diabetes using continuous glucose monitoring rather than self-monitored blood glucose.

Analysis of childhood type 1 diabetes diagnoses across 13 countries indicates that the conditions created by the COVID-19 pandemic worsened pre-existing increasing trends in ketoacidosis at diagnosis.

People taking basal insulin to treat type 2 diabetes experience a significant reduction in the risk for acute complications, which is sustained for at least 2 years after initiating use of the Freestyle Libre, say French researchers.

Adding daily empagliflozin to closed-loop insulin delivery improves time in range but also increases ketone levels in people with type 1 diabetes, shows a randomized trial.

Implementing a subcutaneous insulin protocol for the treatment of diabetic ketoacidosis significantly reduces intensive care admissions and readmission to hospital within 30 days of discharge without increasing hypoglycemia, research shows.

Diabetic ketoacidosis affects around one in 60 pregnant women with type 1 diabetes and is associated with “exceptionally high” perinatal mortality rates, shows research.

Young people with type 1 diabetes are at increased risk for hospitalization for acute complications at the time of transition from pediatric to adult care, say researchers.

Diabetic ketoacidosis is three times more common with type 1 diabetes than with type 2 diabetes, but episode presentation and severity are similar between the two groups, show data presented at the virtual 57th EASD Annual Meeting.

Researchers find the increase in hospital admissions for diabetic ketoacidosis in England during the COVID-19 pandemic was caused by additional admissions of people with new-onset or type 2 diabetes.

The incidence of diabetic ketoacidosis has risen gradually since 2004, with sharper increases occurring among the oldest and most socioeconomically deprived groups, shows an analysis of data from Scotland.

Readmission to hospital within a month of admission for diabetic ketoacidosis is common and associated with an increased mortality risk, say researchers.

Researchers find that people with recurrent diabetic ketoacidosis have an increased rate of mental health problems such as diabetes distress and personality disorder.

Increased BMI and insulin resistance are important predictors of diabetic ketoacidosis risk among people with type 1 diabetes using SGLT2 inhibitors, say the authors of a meta-analysis and meta-regression.

Any amount of residual C-peptide is protective against some type 1 diabetes complications, show findings from a large, population-based study.

Acute kidney injury is common in children with diabetic ketoacidosis and is associated with circulatory volume depletion, greater acidosis, and signs of cerebral injury, US study data show.

Research shows moderate or severe diabetic ketoacidosis is associated with lower IQ and reduced short- and long-term memory in children with type 1 diabetes, with some impairment seen even in newly diagnosed children.

A large population-based study supports an increased risk for diabetic ketoacidosis for users of SGLT2 inhibitors compared with DPP-4 inhibitors, although the absolute risk remains low.

Researchers have identified a marked increase in the proportion of children and adolescents who have diabetic ketoacidosis at the point of type 1 diabetes diagnosis during the COVID-19 pandemic.

UK audit data confirm multiple benefits linked to real-world use of flash glucose monitoring including reduced paramedic callouts and hospital admissions for acute diabetes complications.

Real-world data presented at the virtual ADA 80th Scientific Sessions highlight the benefits of the FreeStyle Libre continuous glucose monitoring system in reducing acute complications in people with type 1 or type 2 diabetes.