Diabetes complications and comorbidities: Hypoglycemia

Automated insulin delivery reduces hypoglycemia in people with type 1 diabetes at increased risk, improving their time spent in target glucose range.

Result from ONWARDS 5 trial show weekly insulin icodec plus a dosing app offers greater reductions in glycated hemoglobin than daily basal insulin analogs for type 2 diabetes.

The results of ONWARDS 2 show significantly improved glycemic control with weekly insulin icodec versus daily insulin degludec, without significantly increased hypoglycemia, in people with type 2 diabetes.

Data from the DPV cohort show a reduced risk for severe hypoglycemia and diabetic ketoacidosis among children and young people with type 1 diabetes using continuous glucose monitoring rather than self-monitored blood glucose.

A health informatics system based on routine clinical data helps physicians to prioritize high-risk people with diabetes, deliver more equitable care, and manage healthcare capacity, report researchers.

The benefits of switching from intermittently scanned to real-time continuous glucose monitoring in adults with type 1 diabetes are sustained for at least 2 years, shows the extension of the ALERTT1 study.

Analysis of participants in the ORACL trial leads researchers to suggest that nonfrail older adults with type 1 diabetes are better off following time in range guidance aimed at younger people.

Blood glucose falls further when people with type 1 diabetes run than when they cycle, show the findings of a systematic review and meta-analysis.

Analysis of childhood type 1 diabetes diagnoses across 13 countries indicates that the conditions created by the COVID-19 pandemic worsened pre-existing increasing trends in ketoacidosis at diagnosis.

People with type 1 diabetes are more likely to have impaired awareness of hypoglycemia if they also report symptoms of anxiety and depression, UK study findings indicate.

Findings from the HIT4HYPOS trial suggest that a high-intensity exercise program may improve hormonal and symptomatic responses to hypoglycemia among people with type 1 diabetes and impaired awareness of hypoglycemia.

Gaining the use of a low blood glucose alert by switching from the FreeStyle Libre 1 to 2 reduces the amount of time people with type 1 diabetes spend in hypoglycemia, report researchers.

People taking basal insulin to treat type 2 diabetes experience a significant reduction in the risk for acute complications, which is sustained for at least 2 years after initiating use of the Freestyle Libre, say French researchers.

A randomized crossover trial shows that both hypoglycemia and rebound hyperglycemia trigger persistent increases in left ventricular function in people with type 1 diabetes.

Switching 1% of standard bolus insulin lispro to a liver-targeted formulation decreases hypoglycemic events without affecting glucose control, OPTI-1 study findings indicate.

Fluctuations in blood glucose levels during the night can adversely impact the psychologic and physical function of people with type 1 diabetes during the following day, report researchers.

Early results suggest that transplantation of fully differentiated stem cell-derived islet cells is a promising approach for achieving glycemic control in people with unstable type 1 diabetes.

The risk for hypoglycemia from an accidental basal insulin overdose is no higher with weekly insulin icodec than with daily glargine U100 in people with type 2 diabetes, report researchers.

Women are more likely than men to experience repercussions of serious or severe hypoglycemia that impact their wellbeing or diabetes management, a study suggests.

The iLet bionic pancreas closed-loop insulin delivery system provides good glucose control without the need for the user to count carbohydrates, show findings from the pivotal trial.