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Diabetes complications and comorbidities

Highlights

Pills arranged as kidneys

12-18-2020 | Dapagliflozin | Highlight | News

DAPA-CKD: Dapagliflozin renoprotective regardless of underlying CKD etiology

A prespecified analysis of data from the DAPA-CKD trial suggests that add-on treatment with dapagliflozin slows decline in renal function among patients with chronic kidney disease irrespective of the underlying etiology.

Kidneys

11-17-2020 | Sotagliflozin | Highlight | News

​​​​​​​Sotagliflozin SCORED cardiovascular risk reduction in people with type 2 diabetes, CKD

Add-on treatment with the SGLT1 and 2 inhibitor sotagliflozin may reduce cardiovascular risk among patients with type 2 diabetes and chronic kidney disease, suggest findings from the SCORED trial published in The New England Journal of Medicine.

emergency_department

08-03-2020 | Hypoglycemia | Highlight | News

Severe hypoglycemia ‘marker rather than cause’ for longer-term type 2 diabetes mortality risk

Severe hypoglycemia in people with type 2 diabetes is associated with later mortality from a wide range of causes, including those for which there is no obvious underlying mechanism, say researchers.

Female archer aiming at target

07-27-2020 | Continuous glucose monitoring | Highlight | News

Dual targets difficult to reach in type 1 diabetes

People with type 1 diabetes treated with multiple daily insulin injections struggle to achieve guideline-recommended targets for time in hypoglycemia while simultaneously reaching their glycated hemoglobin goals, researchers report.

Chalkboard image of patient with heart failure

06-24-2020 | Heart failure | Highlight | News

Heart failure poses greatest CV mortality risk after type 2 diabetes diagnosis

Real-world study findings suggest that heart failure is associated with the greatest increase in mortality risk when compared with other cardiovascular and renal complications among people with newly diagnosed type 2 diabetes.

CGM

06-17-2020 | Continuous glucose monitoring | Highlight | News

Variable CGM benefits in high-risk subgroups

Continuous glucose monitoring is well accepted and reduces time in hypoglycemia among older individuals with type 1 diabetes, report researchers in JAMA.

Gym class jumping on boxes

05-22-2020 | Physical activity | Highlight | News

Hybrid insulin regimen may address type 1 diabetes exercise issues

A proof-of-concept study indicates that taking some basal insulin as a single injection of degludec improves glucose control during and after exercise in people with type 1 diabetes who prefer to remove their insulin pump while exercising.

Motion blur child hospital emergency

05-19-2020 | Children | Highlight | News

DKA prevalence with newly diagnosed pediatric type 1 diabetes remains high

A major study of children from three continents suggests that diabetic ketoacidosis remains unacceptably high among those newly identified with type 1 diabetes and shows few signs of improving.

Cartoon of overweight man walking on a 'cardiovascular tightrope'

05-05-2020 | Prediabetes | Highlight | News

Prediabetes marks increased vascular risk

People who meet the criteria for prediabetes during the 3 years before a type 2 diabetes diagnosis have a higher burden of vascular disease than those who do not, research shows.

Human kidney cross section on scientific background. 3d illustration

04-16-2020 | Nephropathy | Highlight | News

Hypoglycemia risk with even mild renal dysfunction in real-world practice

A large observational study reveals a strong link between reduced kidney function and increased incidence of hypoglycemia in adults with diabetes in routine clinical practice.

Open window

02-10-2020 | Latent autoimmune diabetes of adulthood | Highlight | News

‘Early therapeutic window’ highlighted for LADA

Optimal glycemic control during the first years after a latent autoimmune diabetes of adulthood diagnosis could prevent people’s microvascular complication risk from equaling that seen in those with type 2 diabetes, shows an analysis of the UKPDS.

Gout

01-13-2020 | SGLT2 inhibitors | Highlight | News

Lower gout risk with SGLT2 inhibitors vs GLP-1 receptor agonists

People with type 2 diabetes who are treated with sodium-glucose cotransporter 2 inhibitors are less likely to develop gout than those given glucagon-like peptide-1 receptor agonists, researchers report.

Kidneys

12-20-2019 | SGLT2 inhibitors | Highlight | News

CVD-REAL 3: Renal benefits of SGLT2 inhibitors confirmed in real-world study

Patients with type 2 diabetes who are treated with SGLT2 inhibitors in routine clinical practice have a lower rate of kidney function decline and a reduced risk for adverse renal events compared with those given other glucose-lowering drugs, researchers report.

Heart kidney and nerves

12-10-2019 | Nephropathy | Highlight | News

Nonalbuminuric CKD risks confirmed in type 2 diabetes

People with type 2 diabetes and reduced kidney function in the absence of albuminuria have an increased risk for mortality and major adverse cardiovascular events, despite a low risk for end-stage renal disease, research shows.

Blood test

10-23-2019 | Hypoglycemia | Highlight | News

Fasting C-peptide indicates hypoglycemia risk at basal insulin initiation

Fasting C-peptide levels can “provide valuable information” to guide the approach to titrating basal insulin in new users with type 2 diabetes, say researchers.

Islet cells

10-16-2019 | Islet transplantation | Highlight | News

Islet transplantation benefits endure over 10 years

Three-quarters of people who undergo islet transplantation for type 1 diabetes have sustained graft survival with associated improvements in glucose control, insulin requirements, and hypoglycemia incidence 10 years later, research shows.

CGM_action

10-16-2019 | Continuous glucose monitoring | Feature | Article

CGM time in range: A higher standard for an engaged few?

Simon Heller explains why time-in-range targets are so helpful for people with diabetes… yet handing out continuous glucose monitoring devices willy-nilly could do more harm than good.

Hospital emergency sign

10-03-2019 | Ketoacidosis | Highlight | News

Protocol with point-of-care testing improves speed, accuracy of DKA diagnosis

Implementing a nursing protocol that includes point-of-care testing at triage reduces the time to diabetic ketoacidosis diagnosis and the number of unnecessary intravenous placements in the pediatric emergency department, say researchers.

Kidneys

09-20-2019 | Nephropathy | EASD 2019 | News

Mixed results for PRIORITY diabetic nephropathy trial

The CKD273 proteomic biomarker panel can predict which people with type 2 diabetes will develop detectable diabetic nephropathy, but early intervention with spironolactone does not mitigate this risk, report the PRIORITY investigators.

Luigi Gnudi

09-20-2019 | Nephropathy | Video | Article

Expert commentary: The PRIORITY trial results

Luigi Gnudi discusses the findings of the PRIORITY trial and addresses whether diabetologists should consider intervening earlier in diabetic nephropathy (4:08).