5. Hvidoere Study Group: What Can Be Learned from Observational Studies

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Holl RW, Swift PG, Mortensen HB, Lynggaard H, Hougaard P, Aanstoot HJ, Chiarelli F, Daneman D, Danne T, Dorchy H, Garandeau P, Greene S, Hoey HM, Kaprio EA, Kocova M, Martul P, Matsuura N, Robertson KJ, Schoenle EJ, Sovik O, Tsou RM, Vanelli M, Aman J (2003) Insulin injection regimens and metabolic control in an international survey of adolescents with type 1 diabetes over 3 years: results from the Hvidoere study group. Eur J Pediatr 162(1):22–29CrossRefPubMed

Hoey H, Aanstoot HJ, Chiarelli F, Daneman D, Danne T, Dorchy H, Fitzgerald M, Garandeau P, Greene S, Holl R, Hougaard P, Kaprio E, Kocova M, Lynggaard H, Martul P, Matsuura N, McGee HM, Mortensen HB, Robertson K, Schoenle E, Sovik O, Swift P, Tsou RM, Vanelli M, Aman J (2001) Good metabolic control is associated with better quality of life in 2,101 adolescents with type 1 diabetes. Diabetes Care 24(11):1923–1928CrossRefPubMed

Danne T, Mortensen HB, Hougaard PH, Lynggaard Aanstoot HJ, Chiarelli F, Daneman D, Dorchy H, Garandeau P, Greene SA, Hoey H, Holl RW, Kaprio EA, Kocova M, Robertson KJ, Schoenly E, Sovik O, Swift PG, Tsou RM, Vanelli M, Aman J, Hvidoere Study Group on Childhood Diabetes (2001) Persistent differences among centers over 3 years in glycemic control and hypoglycemia in a study of 3,805 children and adolescents with type 1 diabetes from the Hvidoere Study Group. Diabetes Care 24(8):1342–1347CrossRefPubMed

Mortensen HB, Swift PG, Holl RW, Hougaard P, Hansen L, Bjoerndalen H, de Beaufort CE, Knip M, Hvidoere Study Group on Childhood Diabetes (2010) Multinational study in children and adolescents with newly diagnosed type 1 diabetes: association of age, ketoacidosis, HLA status, and autoantibodies on residual beta-cell function and glycemic control 12 months after diagnosis. Pediatr Diabetes 11(4):218–226CrossRefPubMed

Mortensen HB, Hougaard P, Swift P, Hansen L, Holl RW, Hoey H, Bjoerndalen H, de Beaufort C, Chiarelli F, Danne T, Schoenle EJ, Aman J, Hvidoere Study Group on Childhood Diabetes (2009) New definition for the partial remission period in children and adolescents with type 1 diabetes. Diabetes Care 32(8):1384–1390CrossRefPubMedPubMedCentral

Pörksen S, Hvidoere Study Group on Childhood Diabetes (2008) Variation within the PPARG gene is associated with residual beta-cell function and glycemic control in children and adolescents during the first year of clinical type 1 diabetes. Pediatr Diabetes 9(4 Pt 1):297–302CrossRefPubMed

Pfleger C, Hvidoere Study Group On Childhood Diabetes (2008) Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes. Clin Immunol 128(1):57–65CrossRefPubMed

Kaas A, Pfleger C, Kharagjitsingh AV, Schloot NC, Hansen L, Buschard K, Koeleman BP, Roep BO, Mortensen HB, Alizadeh BZ, Hvidoere Study Group on Childhood Diabetes (2012) Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes. Hvidoere Study Group on Childhood Diabetes. Diabet Med 29(6):734–741CrossRefPubMed

Kaas A, Andersen ML, Fredheim S, Hougard P, Buschart K, Petersen JS, de Beaufort CE, Robertsen KL, Hansen L, Mortensen HB, Nielsen LB, Hvidoere Study Group on Childhood Diabetes (2012) Pro insulin GLP1 and glucagon are associated with partial remission in children and adolescents with newly diagnosed diabetes mellitus. Pediatr Diabetes 13(1):51–58CrossRefPubMed

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Kaas A, Pfleger C, Hansen L, Buschard K, Schloot NC, Roep BO, Mortensen HB, Hvidøre Study Group on Childhood Diabetes and the Hvidoere Study Group on Childhood Diabetes (2010) Association of adiponectin, interleukin (IL)-1ra, inducible protein 10, IL-6 and number of islet autoantibodies with progression patterns of type 1 diabetes the first year after diagnosis. Clin Exp Immunol 161:444–452CrossRefPubMedPubMedCentral

de Beaufort CE, Swift PG, Skinner CT, Aanstoot HJ, Aman J, Cameron F, Martul P, Chiarelli F, Daneman D, Danne T, Dorchy H, Hoey H, Kaprio EA, Kaufman F, Kocova M, Mortensen HB, Njølstad PR, Phillip M, Robertson KJ, Schoenle EJ, Urakami T, Vanelli M et al; Hvidoere Study Group on Childhood Diabetes 2005 (2007) Continuing stability of center differences in pediatric diabetes care: do advances in diabetes treatment improve outcome? The Hvidoere Study Group on Childhood Diabetes. Diabetes Care 30(9):2245–2250

Cameron FJ, Skinner TC, de Beaufort CE, Hoey H, Swift PG, Aanstoot H, Aman J, Martul P, Chiarelli F, Daneman D, Danne T, Dorchy H, Kaprio EA, Kaufman F, Kocova M, Mortensen HB, Njølstad PR, Phillip M, Robertson KJ, Schoenle EJ, Urakami T, Vanelli M, Ackermann RW, Skovlund SE, Hvidoere Study Group on Childhood Diabetes (2008) Are family factors universally related to metabolic outcomes in adolescents with Type 1 diabetes? Diabet Med 25(4):463–468CrossRefPubMed

Swift PG, Skinner TC, de Beaufort CE, Cameron FJ, Aman J, Aanstoot HJ, Castaño L, Chiarelli F, Daneman D, Danne T, Dorchy H, Hoey H, Kaprio EA, Kaufman F, Kocova M, Mortensen HB, Njølstad PR, Phillip M, Robertson KJ, Schoenle EJ, Urakami T, Vanelli M, Ackermann RW, Skovlund SE, Hvidoere Study Group on Childhood Diabetes (2010) Target setting in intensive insulin management is associated with metabolic control: the Hvidoere childhood diabetes study group centre differences study 2005. Pediatr Diabetes 11(4):271–278CrossRefPubMed

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Due P, de Beaufort C, Damsgaard MT, Mortensen HB, Rasmussen M, Ahluwalia N, Skinner T, Swift P, HSG and HBSC consortia et al (2013) Do eating behaviors in the general population account for country variance in glycemic control among adolescents with diabetes: the Hvidoere Study Group and the Health Behaviour in School-Aged Children study. Pediatr Diabetes 14(8):554–561CrossRefPubMed

Neu A, Lange K, Barrett T, Cameron F, Dorchy H, Hoey H, Jarosz-Chobot P, Mortensen HB, Robert JJ, Robertson K, de Beaufort C, Hvidoere Study Group (2015) Classifying insulin regimens – difficulties and proposal for a comprehensive new definition. Pediatr Diabetes 16:402–406CrossRefPubMed

de Beaufort CE, Lange K, Swift PG, Aman J, Cameron F, Castano L, Dorchy H, Fisher LK, Hoey H, Kaprio E, Kocova M, Neu A, Njolstad PR, Phillip M, Schoenle E, Robert JJ, Urukami T, Vanelli M, Danne T, Barrett T, Chiarelli F, Aanstoot HJ, Mortensen HB, Hvidoere Study Group (2013) Metabolic outcomes in young children with type 1 diabetes differ between treatment centers: the Hvidoere Study in Young Children 2009. Pediatr Diabetes 14(6):422–428CrossRefPubMed

Cameron FJ, de Beaufort C, Aanstoot HJ, Hoey H, Lange K, Castano L, Mortensen HB, Hvidoere International Study Group (2013) Lessons from the Hvidoere International Study Group on childhood diabetes: be dogmatic about outcome and flexible in approach. Pediatr Diabetes 14(7):473–480CrossRefPubMed

Redon I, Beltrand J, Martin D, Taupin P, Choleau C, Morandini M, Cahane M, Robert J-J, AJD health care teams (2014) Changes in insulin therapy regimens over 10 yr in children and adolescents with type 1 diabetes attending diabetes camps. Pediatr Diabetes 15:329–335CrossRefPubMed

Maahs DM, Hermann JM, DuBose SN, Miller KM, Heidtmann B, DiMeglio LA, Rami-Merhar B, Beck RW, SSchober E, Tamborlan W, Kapellen TM, Holl RW (2014) DPV Initiative, T1D exchange Network Contracting the clinical care and outcome of 2622 children with type 1 diabetes less than 6 years of age in the United States T1D Exchange and the German/Austrian DPV registries. Diabetologia 57:1578–1585CrossRefPubMed