Pathogenesis

Starting young people on closed-loop insulin delivery within 21 days after type 1 diabetes diagnosis does not slow the decline in their C-peptide levels over the next 12 months, report the CLOuD investigators.

Researchers have characterized an atypical form of diabetes in Indian men with low BMI, which has a unique metabolic profile setting it apart from type 1 and type 2 diabetes.

At least a third of people diagnosed with type 2 diabetes in sub-Saharan Africa are neither overweight nor particularly insulin resistant, say researchers.

A genetic propensity for increased liver fat and lower pancreatic volume is associated with an increased risk for type 2 diabetes, say researchers.

Children at increased genetic risk for type 1 diabetes are more likely to develop the condition if they have multiple, rather than single, islet autoantibodies present at the time of seroconversion, a combined analysis of prospective cohorts shows.

A recurring brief intensive course of insulin every 3 months does not build on metabolic improvements gained from an induction course in people with type 2 diabetes of relatively short duration, say researchers.

Researchers have identified infants as young as 3 months with probable type 1 diabetes, raising the possibility that the disease process could in some cases begin before birth.

Reductions in the function of islet beta cells within the pancreas occur in two distinct phases among individuals with latent autoimmune diabetes of adulthood (LADA), Chinese researchers report.