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Pathogenesis

07-23-2021 | Children | News

Autoantibody variation at seroconversion may indicate future diabetes risk in children

Children at increased genetic risk for type 1 diabetes are more likely to develop the condition if they have multiple, rather than single, islet autoantibodies present at the time of seroconversion, a combined analysis of prospective cohorts shows.

05-20-2021 | Insulin | News

Repeat courses of intensive insulin do not ‘reset the clock’ in type 2 diabetes

A recurring brief intensive course of insulin every 3 months does not build on metabolic improvements gained from an induction course in people with type 2 diabetes of relatively short duration, say researchers.

10-23-2020 | Pathogenesis | News

Type 1 diabetes identified in earliest weeks of life

Researchers have identified infants as young as 3 months with probable type 1 diabetes, raising the possibility that the disease process could in some cases begin before birth.

04-29-2020 | Latent autoimmune diabetes of adulthood | News

LADA beta-cell function shows ‘biphasic’ decline

Reductions in the function of islet beta cells within the pancreas occur in two distinct phases among individuals with latent autoimmune diabetes of adulthood (LADA), Chinese researchers report.

03-16-2020 | Pathophysiology | Highlight | News

Type 1 diabetes endotypes firmed up

Researchers provide further evidence to support two distinct type 1 diabetes endotypes characterized by a more or less aggressive autoimmune response and a younger or older age at onset.

02-14-2020 | Pathogenesis | Highlight | News

Excess weight may hasten type 1 diabetes progression in lower-risk children

A high BMI may contribute to the risk for progressing from single to multiple islet autoantibodies, especially in children who would otherwise be at relatively low risk, show findings from TrialNet.

10-22-2019 | Pathogenesis | News

Genetic study supports causal effect of resting heart rate on type 2 diabetes risk

Researchers have used Mendelian randomization analysis to demonstrate a shared etiology between resting heart rate and the risk for type 2 diabetes.

09-23-2019 | Children | EASD 2019 | News

RISE compares alpha, beta cells in youth vs adults with early type 2 diabetes

The failure of intensive medication to halt beta-cell decline in children with early type 2 diabetes occurs despite them having better baseline beta-cell and alpha-cell function than newly diagnosed adults, say the RISE researchers.

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