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02-11-2020 | Metabolic surgery | News

Longstanding obesity no barrier to bariatric surgery benefits

People who undergo bariatric surgery are just as likely to achieve diabetes remission and reduce their risk for microvascular complications regardless of when they first became obese, suggest findings from the Swedish Obese Subjects study.

02-07-2020 | Pregnancy | News

Maternal diabetes, obesity may raise risk for neuropsychiatric disorders in children

Children born to mothers with diabetes and severe obesity have an elevated risk for developing neuropsychiatric disorders, researchers report.

01-30-2020 | Metabolic surgery | News

Bariatric surgery benefits persist even in face of diabetes relapse

Late relapse of type 2 diabetes is relatively common after bariatric surgery, but does not negate the metabolic health benefits of the procedure, a study shows.

01-28-2020 | Adolescents | News

Mental health continuing issue for adolescents after bariatric surgery

Adolescents who undergo bariatric surgery do not as a rule experience resolution of mental health problems, say researchers.

01-24-2020 | Obesity | News

Severe obesity may be associated with impaired cognition

Severely obese people show evidence of impaired cognition even when they have no signs of prediabetes or diabetes, but retinopathy and nephropathy only occur in those with hyperglycemia, US research shows.

01-03-2020 | Obesity | News

Duration of women’s obesity affects type 2 diabetes risk

The length of time that a young woman has been obese together with its magnitude can collectively impact on the risk for developing type 2 diabetes, an Australian study has revealed.

01-03-2020 | Obesity | News

Lower BMI likely protective against diabetes regardless of other risk factors

A Mendelian randomization analysis suggests that having a lower bodyweight will protect people against type 2 diabetes regardless of whether they have a high genetic risk or a family history of the condition.

12-05-2019 | Diet | News

Time-restricted eating acceptable and beneficial for people with metabolic syndrome

Restricting eating to within a 10-hour daily window results in weight loss and metabolic benefits for people with metabolic syndrome, report researchers in Cell Metabolism.

11-27-2019 | Metabolic surgery | Highlight | News

Preoperative diabetes duration may affect remission rates after bariatric surgery

Swedish research suggests that determining type 2 diabetes duration prior to bariatric surgery could help prioritize those patients most likely to achieve diabetes remission.

11-11-2019 | Obesity | Highlight | News

Online coaching helps with weight loss maintenance

People who are trying to maintain weight loss with the help of electronic health records-based tracking tools do significantly better if they are given access to an online coach, shows a randomized trial.

11-05-2019 | Glycemic control | News

Group medical visits may be more effective with added intensive weight management

Adding intensive weight management to group medical visits for type 2 diabetes leads to greater weight loss, reduced medication use, and fewer hypoglycemic events, with a similar improvement in glycemic control, research shows.

10-31-2019 | Metabolic surgery | Highlight | News

Trial results support gastric bypass as ‘procedure of choice’ for diabetes remission

People with obesity and type 2 diabetes who undergo gastric bypass surgery have higher rates of diabetes remission after 1 year than those undergoing sleeve gastrectomy, indicate findings from the Oseberg trial.

10-09-2019 | Obesity | News

Complex associations between weight regain and cardiometabolic risk

The effect of weight regain on cardiometabolic risk in people with type 2 diabetes varies according to sex, initial weight loss, and the particular risk factor under study, shows an analysis of the Look AHEAD trial.

09-05-2019 | Obesity | Highlight | News

Metabolic surgery may improve cardiovascular prognosis in type 2 diabetes

People with type 2 diabetes and obesity who undergo metabolic surgery have a significantly lower risk for major adverse cardiovascular events than those who do not receive surgery, observational study data show.

09-03-2019 | Medications | News

Diabetes medications need review ahead of weight-loss interventions

The specific medications people are taking for diabetes can affect their success when they undertake a weight-loss program, say researchers.

08-20-2019 | Metabolic surgery | News

Succinate levels may predict diabetes remission after bariatric surgery

Individuals with lower preoperative levels of serum succinate are more likely to achieve remission of type 2 diabetes after bariatric surgery than those with higher levels of the metabolite, study results suggest.

08-14-2019 | Gestational diabetes | News

Metformin exposure during pregnancy may impact postnatal growth trajectory

Infants born to mothers with gestational diabetes treated with metformin have lower birthweight, but experience accelerated postnatal growth and have higher BMI in childhood, compared with those whose mothers were treated with insulin, suggest findings from a meta-analysis.

08-12-2019 | Metabolic surgery | Highlight | News

Bariatric surgery linked to late adverse events

People who undergo bariatric surgery have a lower long-term risk for mortality, but a higher risk for adverse events such as gastrointestinal and nutritional disorders, compared with those who do not undergo surgery, researchers report.

Read the linked commentary from John Wilding

08-02-2019 | Pregnancy | News

Maternal blood glucose levels, BMI linked to stillbirth risk

A Scottish study has identified glycated hemoglobin levels and BMI as modifiable risk factors for stillbirth among pregnant women with diabetes.

07-18-2019 | Liraglutide (obesity) | News

Brain may put brakes on liraglutide weight loss effect

A small neuroimaging study suggests that taking liraglutide over the medium to long term may provoke a counter-regulatory response in the brain, diminishing the medication’s weight loss effect.

06-06-2019 | Liraglutide (T2DM) | News

Liraglutide may be an option for people with unresolved type 2 diabetes after metabolic surgery

Findings from the GRAVITAS trial indicate that use of the GLP-1 receptor agonist liraglutide alongside a diet and physical activity intervention may improve glycemic control among people with persistent or recurrent type 2 diabetes after bariatric surgery.

06-03-2019 | Lifestyle interventions | News

Extended behavioral intervention suggested for optimal glycemic control

Obese adults with prediabetes may need a longer-than-recommended course of behavioral weight loss treatment to optimize improvements in glycemic control, US researchers report.

05-17-2019 | Adolescents | News

Teen-LABS reports 5-year gains and drawbacks of bariatric surgery in adolescents

Adolescents who undergo bariatric surgery are more likely than adult patients to have remission of diabetes and hypertension, but require more reoperations, show the 5-year outcomes of the Teen-LABS cohort.

05-15-2019 | Diet | News

DiRECT/Counterweight-Plus intervention could be cost-effective long-term

Type 2 diabetes remission can be achieved within 1 year at a cost below the average annual cost of diabetes management, even when including complications, shows an economic evaluation of the DiRECT/Counterweight-Plus weight management program.

04-23-2019 | Metformin | News

Metformin may help people at high diabetes risk to maintain weight loss

Fifteen years of follow-up of the DPP trial shows that although people initially lost more weight with the intensive lifestyle intervention, those assigned to metformin did better at keeping the weight off in the long term.

03-08-2019 | Obesity | News

Similar weight-loss outcomes with one anastomosis, Roux-en-Y gastric bypass procedures

Findings from the YOMEGA trial indicate that the one anastomosis gastric bypass procedure is noninferior to standard Roux-en-Y gastric bypass in terms of weight loss and metabolic outcomes.

03-06-2019 | Diet | DUKPC 2019 | News

Diabetes remission durable for a third of DiRECT participants

Just over a third of people who undertook a period on a very-low-calorie diet in the DiRECT trial to tackle type 2 diabetes are in remission 24 months later, the investigators have reported.

03-05-2019 | Physical activity | Highlight | News

Behavioral intervention has durable physical activity effect in type 2 diabetes

A behavioral intervention has lasting effects on physical activity levels, fitness, and vascular risk in people with type 2 diabetes, show the 3-year results of the randomized Italian Diabetes and Exercise Study 2.

02-07-2019 | Metabolic surgery | News

Diabetes remission common, but unstable, after Roux-en-Y gastric bypass

Almost three-quarters of patients who undergo Roux-en-Y gastric bypass experience diabetes remission within 1 year of surgery, but nearly one-third subsequently relapse, population-based study data show.

01-16-2019 | Obesity | News

Gastric bypass pros and cons reported for type 2 diabetes patients

Overweight and obese patients with type 2 diabetes who undergo gastric bypass have significantly lower risks for death, cardiovascular disease, and severe kidney disease than those who do not have such surgery, Swedish research shows.

12-07-2018 | Pregnancy | News

Metformin plus lifestyle advice does not improve pregnancy outcomes for obese women

Giving pregnant obese women metformin in addition to dietary and lifestyle advice does not reduce the likelihood of them having a baby with a high birthweight, show the results of the GRoW randomized trial.

10-31-2018 | Pregnancy | News

Late pregnancy dysglycemia a concern for children of obese mothers

Dysglycemia in the last trimester of pregnancy despite prior negative testing for gestational diabetes may predispose the offspring of obese mothers to increased weight gain during early childhood, German research shows.

10-29-2018 | Metabolic surgery | News

Effectiveness of bariatric surgery varies across procedures

Patients undergoing Roux-en-Y gastric bypass experience significantly greater weight loss for at least 5 years than those undergoing sleeve gastrectomy and adjustable gastric banding, but are at greater risk for adverse events, research shows.

10-25-2018 | Obesity | News

Even partial weight loss intervention adherence can pay dividends

Less than perfect attendance at commercial weight loss programs does not consign participants to failure, study findings show.

10-24-2018 | Obesity | News

BMI trajectory linked to hyperglycemia risk irrespective of BMI level

The rate at which BMI changes throughout childhood and adolescence is significantly associated with adult hyperglycemia, independent of BMI level at specific time points, study findings indicate.

10-16-2018 | Metabolic surgery | medwireNews | News

Marked reduction in vascular events in diabetes patients after bariatric surgery

An observational study published in JAMA demonstrates a substantial reduction in the risk for hard cardiovascular endpoints in obese patients with type 2 diabetes who have undergone bariatric surgery.

10-10-2018 | Risk factors | EASD 2018 | News

Weight gain since childhood imposes high diabetes risk

The risk for type 2 diabetes in overweight people is higher in those who gained weight after the age of 10 years than in those who were already overweight at that time, researchers report.

10-10-2018 | Laparascopic gastric band | EASD 2018 | News

Gastric banding has little effect on beta-cell decline in early type 2 diabetes

The results of the adult surgery study from the RISE consortium show that gastric banding has only a small effect on the deterioration of beta-cell function relative to metformin, despite causing markedly greater weight loss.

10-09-2018 | Children | EASD 2018 | News

RISE pediatric findings consistent over longer term

The RISE investigators have reported a continued lack of effect of early intensive therapy on beta-cell function decline in children with prediabetes or early type 2 diabetes.

10-09-2018 | Diabetes prevention | EASD 2018 | News

Mixed results from the diabetes prevention PREVIEW project

The PREVIEW project investigators have reported broadly positive results, but tempered by issues such as a high dropout rate.

10-05-2018 | Obesity | News

Preschool weight gain confers highest risk for teenage obesity

Almost all children who are obese by the age of 3 years remain obese into adolescence, shows a study in The New England Journal of Medicine.

10-05-2018 | Lorcaserin | EASD 2018 | News

Weight loss with lorcaserin linked to improved glycemic profile

Losing weight in the CAMELLIA-TIMI 61 trial was associated with a significantly reduced risk for developing type 2 diabetes, the investigators have reported at the 54th EASD Annual Meeting in Berlin, Germany.

09-28-2018 | Diet | News

Total diet replacement approach achieves weight loss goals

Obese primary care patients referred to a total diet replacement program run by a commercial provider achieve substantial amounts of weight loss a year later, show findings from a randomized trial.

09-10-2018 | Gestational diabetes | News

Gestational diabetes has minimal impact on childhood obesity risk

Maternal BMI prior to and during early pregnancy has a greater impact than gestational diabetes and hypertension, and pre-eclampsia on the risk for increased BMI in childhood, study findings indicate.

08-27-2018 | Adolescents | News

Ethnicity influences reversibility of dysglycemia in obese children

Impaired glucose tolerance in obese youths frequently reverts to normal, although the chances of this happening are strongly influenced by ethnicity, researchers report in The Lancet Child & Adolescent Health.

08-26-2018 | Lorcaserin | Highlight | News

Neutral cardiovascular safety for lorcaserin in CAMELLIA-TIMI 61

The weight-loss medication lorcaserin neither increases nor reduces cardiovascular risk, report the CAMELLIA–TIMI 61 investigators.

08-21-2018 | Metabolic surgery | News

Novel scoring system identifies longer term type 2 diabetes remission after gastric bypass

A novel scoring system that could be used in routine clinical care can predict remission from type 2 diabetes 5 years after gastric bypass surgery, researchers report.

08-20-2018 | Pregnancy | News

Metformin may not improve pregnancy outcomes for obese women

The authors of a systematic review find insufficient evidence to support the use of metformin to improve pregnancy outcomes among obese women.

08-17-2018 | Semaglutide | Highlight | News

Semaglutide shows promise for weight management

Findings from a dose-ranging phase II trial published in The Lancet suggest that semaglutide, in combination with lifestyle intervention, may aid weight loss in people with obesity who do not have diabetes.

08-16-2018 | Risk factors | News

Weight gain after smoking cessation could temporarily increase diabetes risk

Study results published in The New England Journal of Medicine suggest that people who gain weight after stopping smoking may experience a temporary increase in their risk for type 2 diabetes.

08-06-2018 | Metabolic surgery | Highlight | News

Real-world bariatric surgery data show microvascular protection

Obese patients with type 2 diabetes who undergo bariatric surgery achieve large reductions in their risk for microvascular complications, shows a real-world study.

07-12-2018 | Liraglutide (T2DM) | News

Predictors of liraglutide response in clinical practice reported

Factors including bodyweight and treatment duration predict response to liraglutide in patients with type 2 diabetes treated in clinical practice, report researchers.

06-24-2018 | Metabolic surgery | ADA 2018 | News

Risks and benefits of gastric bypass surgery shown in obese patients with type 2 diabetes

Gastric bypass surgery benefits obese patients with type 2 diabetes in many ways, but such benefits come at a cost, show data presented at the ADA’s 78th Scientific Sessions in Orlando, Florida.

05-31-2018 | Obesity | Highlight | News

Yet more evidence against metabolically healthy obesity

Another two large studies have demonstrated that people who appear to be in good health despite being obese do not remain so for long.

05-18-2018 | Liraglutide (T2DM) | News

Real-world data support liraglutide use in obese patients

Obese patients with type 2 diabetes who receive treatment intensification with liraglutide may have better glycemic control than those given basal insulin, researchers report.

05-01-2018 | Obesity | Highlight | News

Targeting habits may lead to sustained weight loss

Findings of a randomized trial suggest that challenging people’s habits can lead to sustained weight loss, even if the habits targeted have nothing to do with healthy eating.

04-25-2018 | Screening | News

Percent body fat adds value to BMI when screening for abnormal blood glucose

Adding body fat percentage to BMI improves the classification of individuals at risk for abnormal blood glucose, US researchers report.

04-11-2018 | Latent autoimmune diabetes of adulthood | News

Excessive weight linked to increased LADA risk

Being overweight or obese is associated with a significantly increased risk for the development of latent autoimmune diabetes in adults, especially when combined with a familial history of diabetes, population-based study data show.

04-05-2018 | Obesity | Highlight | News

Weight loss before puberty may mitigate excess diabetes risk associated with childhood overweight

Children who are overweight only have an increased risk for type 2 diabetes in adulthood if they remain overweight beyond the age of 13 years, according to the results of a large Danish study.

03-23-2018 | Lifestyle interventions | News

Weight loss intervention may reduce proportion of life spent disabled in type 2 diabetes

Analysis of data from the Look AHEAD trial suggests that a long-term intensive lifestyle intervention could delay the onset of physical disability among overweight and obese patients with type 2 diabetes.

03-20-2018 | Diabetes prevention | News

NHS DPP uptake exceeding expectation

The latest update from the NHS Diabetes Prevention Programme shows that more people than expected are engaging with the scheme.

03-20-2018 | Diet | News

DiRECT: Effects on insulin and liver fat revealed

Researchers from the DiRECT trial have reported large positive effects on liver fat and insulin secretion among people who achieved type 2 diabetes remission in response to a very-low-calorie diet.

03-19-2018 | Obesity | News

Further evidence challenges obesity paradox

UK Biobank data add to the evidence challenging the existence of the obesity paradox by showing that cardiovascular disease risk increases linearly with increasing adiposity in middle-aged men and women.

03-16-2018 | Gestational diabetes | News

Limiting weight gain after gestational diabetes diagnosis could help prevent complications

Women with gestational diabetes who gain weight late in pregnancy have an increased risk for adverse birth outcomes, study results presented at the 2018 Diabetes UK Professional Conference in London suggest.

03-08-2018 | Neuropathy | News

Obesity, older age associated with higher polyneuropathy risk

Older patients with type 2 diabetes and those with markers of obesity have an increased risk for diabetic polyneuropathy, results of a longitudinal study suggest.

02-21-2018 | Diet | News

Low-fat vs low-carbohydrate diets: Both effective for weight loss

The amount of weight loss achieved with a healthy low-fat diet is no different to that achieved with a healthy low-carbohydrate diet, according to US researchers.

02-14-2018 | Metabolic surgery | News

Bariatric surgery associated with discontinuation of antidiabetes treatment

Obese patients who undergo bariatric surgery are significantly less likely to require treatment for diabetes 6 years post-surgery compared with those who do not undergo such procedures, study findings indicate.

01-25-2018 | Obesity | News

More evidence for ‘social contagion’ in obesity

Researchers have found that the bodyweights of family members of military personnel tend to change to match what is predominant in their area of posting.

01-16-2018 | Metabolic surgery | News

Clear but diminishing returns 5 years after diabetes surgery

The 5-year outcomes of the Diabetes Surgery Study show that the benefits of gastric bypass remain but are of smaller magnitude compared with the 1-year results.

01-12-2018 | Diet | News

Group CBT fails to halt weight regain

Findings of a randomized trial indicate that engaging in group cognitive behavioral therapy does not help people to maintain weight loss after a very-low-calorie diet.

01-11-2018 | Diet | News

Genetic obesity predisposition no barrier to healthy diet benefits

Eating a healthy diet is of particular benefit for people with high genetic risk for obesity, report researchers in The BMJ.

01-11-2018 | Obesity | News

Bariatric surgery linked to increased suicide risk

Obese patients who undergo bariatric surgery are more likely to self-harm or die by suicide than those who undergo nonsurgical management, but the absolute risk is low, suggests an analysis of two Scandinavian cohorts.

12-20-2017 | Diet | News

Structured weight management programs work in the real world

Real-life data show that a structured weight management program can lead to sustained weight loss, improved glycemic control, and a reduced need for medication in patients with type 2 diabetes.

12-18-2017 | Diet | News

Modifying dietary energy density may be key to weight loss

Research suggests that what people trying to lose weight choose to eat may be at least as important as what they avoid.

12-01-2017 | Obesity | News

Surrogate BMI approach supports overweight mortality risk

A novel approach of using children’s BMI as a surrogate for their parents’ weight confirms that overweight and obesity increase people’s mortality risk.

11-29-2017 | Prediabetes | News

Exercise duration may be as important as intensity for people with prediabetes

Objectively measured physical activity is associated with a reduction in cardiometabolic risk markers among people with prediabetes, and the total time spent being active is at least as important as exercise intensity, researchers report.

11-28-2017 | Epidemiology | News

More than one in 20 cancer cases attributed to diabetes, BMI

Researchers say that 5.6% of all cancers globally are attributable to the combined effects of diabetes and high BMI.

11-27-2017 | Obesity | News

Patient factors have greatest influence on weight clinic attendance

Patient-level characteristics such as age, BMI, and deprivation level have a greater influence on an individual’s likelihood of attending a specialist weight management service than do practice-level characteristics, UK study data show.

11-23-2017 | Cardiovascular outcomes | News

Intensive diabetes treatment reduces CVD risk even with excessive weight gain

Intensive treatment of type 1 diabetes appears to reduce the risk for cardiovascular disease events even in those who gain excessive weight, but improved management of cardiovascular risk factors and revascularization may be needed.

10-31-2017 | Physical activity | News

Active commuting benefits confirmed in randomized trial

A randomized controlled trial confirms previous observational findings that active commuting is an effective means of reducing body fat, equivalent to doing five sessions of vigorous activity per week.

10-27-2017 | Obesity | News

Metabolically healthy obese do not remain so for long

Findings from the ARIC cohort show that people who are metabolically healthy but obese are at an increased risk for developing metabolic abnormalities, particularly dysglycemia.

10-17-2017 | Prediabetes | News

Teaming up with commercial weight management providers aids type 2 diabetes prevention

A partnership between primary care and commercial weight management providers could help reduce the risk for type 2 diabetes among patients with hyperglycemia, UK study findings show.

09-22-2017 | Physical activity | News

PURE study shows global physical activity benefits

The PURE study shows that the cardiovascular disease and mortality risk reductions attainable with regular physical activity apply regardless of whether people live in countries with high, middle, or low income.

09-21-2017 | Type 2 diabetes | EASD 2017 | News

Novel compounds show promise for type 2 diabetes

Study results presented at the EASD annual meeting in Lisbon, Portugal, demonstrated the potential of several novel therapies for the treatment of obesity-related metabolic dysfunction and type 2 diabetes.

09-20-2017 | Metabolic surgery | News

Gastric bypass results in ‘near-complete’ long-term diabetes prevention

Research shows that patients who undergo Roux-en-Y gastric bypass are extremely unlikely to develop diabetes over the following decade, and a large proportion of those who have the condition at the time of surgery achieve remission.

09-13-2017 | GLP-1 agonists | EASD 2017 | News

Incretins research update

One of the first original research sessions of EASD 2017 included updates from the TECOS, SUSTAIN 6, and DURATION-7 and -8 trials.

09-11-2017 | Obesity | News

Metabolically healthy obese concept overturned

A study of 3.5 million people strengthens the evidence against the notion that obesity is only a health risk if people also have metabolic abnormalities.

08-29-2017 | Diet | News

PURE study adds pieces to dietary puzzle

Two analyses of the Prospective Urban Rural Epidemiology cohort associate low dietary fat and high carbohydrate intake with an atherogenic lipid profile and increased mortality.

08-16-2017 | Obesity | News

EPIC findings refute metabolically healthy obesity concept

Twelve years of follow-up data from the EPIC study support the assertion that obesity is a cardiovascular risk factor in its own right, even in the absence of metabolic abnormalities.

08-10-2017 | Children | News

Genetics support childhood adiposity and type 1 diabetes link

Genetic variants associated with childhood body mass index correlate with the risk for type 1 diabetes, suggests an analysis of genome-wide association studies.

08-09-2017 | Metabolic surgery | News

Gastric bypass protects against all-cause death only in patients with diabetes

The all-cause mortality benefits of Roux-en-Y gastric bypass surgery are predominantly driven by patients who have diabetes at the time of surgery, according to the results of an observational study.

08-07-2017 | Gestational diabetes | News

Interpregnancy weight gain linked to gestational diabetes risk

Mothers who gain weight between their first and second pregnancies have a higher risk for gestational diabetes than those who maintain a stable weight, an analysis of the Medical Birth Registry of Norway suggests.

07-28-2017 | Metabolic surgery | News

Earlier intervention may boost bariatric surgery effectiveness

A study suggests that obese patients may improve their chances of becoming non-obese and reversing comorbidities such as diabetes if they undergo bariatric surgery before their body mass index reaches 40 kg/m2.

07-26-2017 | Adolescents | News

Poor lifestyle intervention adherence may dilute effectiveness in youths with type 2 diabetes

Session attendance was only moderate and self-monitoring very poor in youths with type 2 diabetes who participated in the TODAY lifestyle programme, an analysis shows.

07-20-2017 | Cardiovascular outcomes | News

Machine learning hints at complex treatment effects in Look AHEAD

A machine-learning analysis suggests the existence of heterogeneous treatment effects in the Look AHEAD trial, which could account for the overall neutral effect of the study intervention on cardiovascular outcomes.

07-05-2017 | Obesity | News

More genetic evidence for BMI cardiometabolic risk

A mendelian randomization analysis adds to the evidence that body mass index leads directly to type 2 diabetes, elevated blood pressure, and coronary heart disease.

07-04-2017 | Metformin | News

Mixed results from randomised trial of metformin in obese children

A randomized controlled trial shows some benefit of metformin treatment in prepubertal children with obesity, but not in pubertal participants.

06-30-2017 | Obesity | News

Unstable control groups may create ‘healthy obesity’ impression

Research suggests that unaccounted changes in the health and weight of control groups over time may partly account for the apparently benign effects of being obese but metabolically healthy.

06-23-2017 | Obesity | News

Poor-quality evidence for lifestyle interventions in overweight children

Cochrane reviewers have assessed the effectiveness of behavior-changing interventions in overweight and obese children, finding an indication of benefit but based on mostly low-quality evidence.

06-20-2017 | Obesity | News

Global Burden of Disease study highlights ongoing obesity epidemic

The 2015 Global Burden of Disease study shows that the prevalence of obesity continues to rise, adding to the burden of obesity-related mortality.

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